长链非编码RNA在慢性阻塞性肺疾病中的表达及其作用研究进展

Progress in the expression of long-stranded noncoding RNA and their role in chronic obstructive pulmonary disease

慢性阻塞性肺疾病(chronic obstructive pulmonary disease, COPD)是一种可以预防和治疗的以持续呼吸道症状和气流受限为主要特征的慢性肺部疾病。长链非编码RNA(long non-coding RNA, lncRNA)是一类具有较长核苷酸链的转录产物,可以通过多种形式调控相关分子的表达来发挥其多种生物学效应。近年来已被证明,lncRNA可通过调控炎症反应、氧化应激及细胞凋亡等多种分子生物学过程参与COPD的病理反应,已逐渐成为诊断和治疗COPD的重要靶点。本文通过对IncRNA在COPD的表达、氧化应激及人肺微血管内皮细胞凋亡中的表达、作用及其病理机制的研究进展进行综述,以期为COPD的诊断和疗效评估提供新的思路和方向。

Chronic obstructive pulmonary disease(COPD)is a kind of preventable and treatable chronic lung disease characterized by persistent respiratory symptoms and airflow limitation.Long non-coding RNA(lncRNA)is a class of transcription products with long nucleotide chains that exert a variety of biological effects by regulating the expression of related molecules in various forms.In recent years,it has been demonstrated that lncRNA can be involved in the pathological response of COPD by regulating various molecular biological processes such as inflammatory response,oxidative stress and apoptosis,and have gradually become an important target for the diagnosis and treatment of COPD.In this paper,we reviewed the research progress of lncRNA expression in COPD,oxidative stress,human pulmonary microvascular endothelial cells apoptosis,and their role in pathological mechanisms,with the aim of providing new ideas and directions for the diagnosis and efficacy assessment of COPD.