含3,5-二正丁氧基苯基钌配合物的合成及抗菌活性研究

Synthesis and Antibacterial Activities of Ruthenium Complexes Containing 3,5-di-butyric Phenyl Groups

以含3,5-二正丁氧基苯基取代邻菲啰啉衍生物(DBPIP)为主配体合成了一个多吡啶钌配合物Ru-1。通过最低抑菌浓度、时间杀伤曲线、生物被膜实验、耐药性评价等探索了钌化合物对金黄色葡萄球菌的抗菌活性。通过大蜡螟幼虫感染模型研究了Ru-1的体内抗菌活性。结果表明,此钌配合物对金黄色葡萄球菌具有优良的抗菌活性。

A polypyridine ruthenium complexes were synthesized with 3,5-di-butyxyphenyl derivatives as the main ligand(DBPIP):Ru-1.The antibacterial activities of ruthenium complexes against S.aureus was evaluated by the minimum inhibitory concentration,time killing curve,biofilm experiments and drug resistance study experiments.The antibacterial activity of Ru-1 was investigated by the model of infection.The results showed that this ruthenium complexes showed excellent antibacterial activity against S.aureus.