微小RNAs在胆管癌发生发展和诊治中的作用

Roles of microRNAs in the development,diagnosis and treatment of cholangiocarcinoma

胆管癌是一种起源于胆道上皮的恶性肿瘤,其发病率低但致死率高,患者被确诊时大多已处于晚期阶段,即使进行及时有效的外科手术干预,其预后效果仍然不尽人意。这就要求临床医师可以早期发现、诊断,进而早期采取措施进行治疗。本综述旨在概述微小RNAs(miRNAs)在胆管癌发生、发展和诊治中的作用,为临床工作提供参考意义。

Cholangiocarcinoma is a malignant tumor originating from biliary epithelium,so that its incidence rate is relatively low,but the fatality rate is high.Most patients are at late stage when they are diagnosed.Even with timely and effective surgical intervention at the time,the prognosis is still unsatisfactory.Early detection,diagnosis,and treatment is essential.This review aims to summarize the role of microRNAs(miRNAs)in the development,diagnosis and treatment of cholangiocarcinoma and provide references for clinical work.