CXCL5在2型糖尿病与恶性肿瘤相关性研究进展

Research Progress of CXCL5 in the Correlation Between Type 2 Diabetes Mellitus and Malignant Tumor

糖尿病(diabetes mellitus,DM)和恶性肿瘤(malignant tumor,MT)是影响人类身心健康的两大疾病,胰岛素抵抗是2型糖尿病(type II diabetes mellitus,T2DM)的主要发病机制。巨噬细胞在肿瘤免疫应答过程中起重要作用,且在糖尿病患者中高度浸润并产生C-X-C基序趋化因子配体5(chemokine C-X-C motif ligand 5,CXCL5)。肿瘤相关巨噬细胞(tumourassociated Macrophages,TAMs)/M2型巨噬细胞高度浸润于肿瘤微环境(tumor microenvironment,TME)中并分泌CXCL5,CXCL5可通过促进肿瘤微血管生成及与其靶基因结合进一步调节TME进而影响MT的发生、发展及预后。本文就CXCL5的分子特征、相关通路以及CXCL5在T2DM与MT相关性中的研究进展做一评述,以期为临床在T2DM与MT的治疗和改善结局方面开启新思路与新方法。

Diabetes mellitus(DM)and malignant tumor(MT)are two major diseases that affect human physical and mental health.Insulin resistance is the main pathogenesis of type 2 diabetes mellitus(T2DM).Macrophages play an important role in the tumor immune response and highly infiltrate and produce C-X-C motif chemokine ligand 5(CXCL5)in diabetic patients.Tumor-associated macrophages(TAMs)/M2 macrophages highly infiltrate and secrete CXCL5 in the tumor microenvironment(TME).CXCL5 can fur⁃ther regulate TME by promoting tumor angiogenesis and combining with its target gene,thus affecting the occurrence,development and prognosis of MT.In this paper,the molecular characteristics and related pathways of CXCL5 as well as the research progress of CXCL5 in the correlation between T2DM and MT were elaborated,looking forward to open up new ideas and methods for the clinical treatment of T2DM and MT and improving the outcome.