炎症性肠病患者与代谢综合征的相关性分析

Analysis of the correlation between patients with inflammatory bowel disease and metabolic syndrome

目的 探索炎症性肠病(inflammatory bowel disease,IBD)和代谢综合征(metabolic syndrome,MS)之间的相关性。方法 选取2020年1月至2023年8月就诊于新疆维吾尔自治区人民医院的97例溃疡性结肠炎(ulcerative colitis,UC)患者和63例克罗恩病(crohn′s disease,CD)患者为病例组,同期来院体检的健康体检者320例为对照组。收集所有研究对象的一般情况和相关检验及检查结果。整理资料,计算体重指数(body mass index,BMI)及MS组分个数,统计代谢相关性脂肪性肝病(metabolic associated fatty liver disease,MAFLD)和MS的发病情况,并分析UC、CD患者同上述一般因素及MS相关指标水平之间的关系。结果 UC组和CD组患者合并高血压、糖尿病及MAFLD的比率均显著高于对照组(P<0.05)。多因素Logistic回归分析显示,MS相关指标水平与IBD之间存在一定程度的相关性。具体来说,高血压史、糖尿病史、甘油三酯、高密度脂蛋白、低密度脂蛋白、舒张压、BMI与UC发病风险相关(P<0.05);糖尿病史、高密度脂蛋白、低密度脂蛋白、收缩压与CD发病风险相关(P<0.05)。结论 MS相关指标水平与IBD之间存在一定相关性,IBD患者MS的发生率较高。健康人群应通过促进科学的生活方式、合理饮食、控制体重等以减少IBD和MS共病的发生率,提高生活质量。

Objective Exploring the correlation between inflammatory bowel disease and metabolic syndrome.MethodsNinety-seven patients with ulcerative colitis(UC) and 63 patients with Crohn′s disease(CD) attending the People′s Hospital of Xinjiang Uygur Autonomous Region from January 2020 to August 2023 were selected as the case group,and 320 healthy medical checkups coming to the hospital during the same period were selected as the control group.The general condition,and the results of related tests and examinations were collected from all the study subjects.The data were collated,the body mass index(BMI) and the number of MS groups were calculated,the incidence of metabolic associated fatty liver disease(MAFLD) and MS was counted,and the relationship between UC and CD patients and the above general factors and MS-related indexes was analyzed.We also analyzed the relationship between patients with UC and CD and the above general factors and MS-related indexes.Results The rates of combined hypertension,diabetes mellitus and MAFLD were significantly higher in patients in both the UC and CD groups than in the control group(P<0.05).Multifactorial logistic regression analysis showed a degree of correlation between the levels of MS-related indicators and IBD.Specifically,history of hypertension,history of diabetes,triglycerides,high-density lipoprotein,low-density lipoprotein,diastolic blood pressure,and BMI were associated with the risk of developing UC(P<0.05);history of diabetes,high-density lipoprotein,low-density lipoprotein,and systolic blood pressure were associated with the risk of developing CD(P<0.05).Conclusion There is a correlation between the levels of MS-related indicators and IBD,and the incidence of MS is higher in patients with IBD.Healthy people should reduce the incidence of co-morbidities of IBD and MS and improve the quality of life by promoting a scientific lifestyle,rational diet,and weight control.