益肠抗癌方对结肠癌术后化疗患者疗效、免疫功能及肠黏膜屏障的影响

Effect of yichang Anticancer Prescription on Therapeutic Effect,Immune Function and Intestinal Mucosal Barrier in Patients with Postoperative Chemotherapy for Colon Cancer

目的:探究结肠癌术后化疗患者应用益肠抗癌方对肠黏膜屏障及免疫功能的影响。方法:选取商丘市第一人民医院2020年12月—2022年12月82例结肠癌术后患者作为研究对象,采用随机数字表法进行分组,对照组给予化疗方案,观察组加用益肠抗癌方,比较2组患者疗效、免疫功能免疫球蛋白M、免疫球蛋白G免疫球蛋白A及肠黏膜屏障血管内皮生长因子、转化生长因子-β1、血浆内毒素含量、尿乳果糖/甘露醇比值及不良反应。结果:治疗8周后,观察组患者免疫球蛋白G、A、M水平高于对照组(P<0.05);观察组内毒素水平及尿乳果糖/甘露醇比值低于对照组(P<0.05),血管内皮生长因子、转化生长因子-β1水平低于对照组(P<0.05);观察组总有效率63.41%高于对照组41.46%(P<0.05);观察组发生胃肠道反应、周围神经病变及肝功能异常例数均低于对照组(P<0.05)。结论:应用益肠抗癌方治疗结肠癌术后化疗患者效果明显,可改善患者肠黏膜屏障功能及免疫功能,并减少化疗引起的不良反应,值得临床参考应用。

Objective:To explore the effect of Yichang Kangcan Recipe on intestinal mucosal barrier and immune function in patients undergoing postoperative chemotherapy for colon cancer.Methods:82 patients with colon cancer after surgery in Shangqiu First People's Hospital from December 2020 to December 2022 were selected as the research subjects,and were divided into groups using the random number table method.The control group was given a chemotherapy regimen,and the observation group was additionally treated with Yichangkang.Cancer prescription,compare the efficacy,immune function [Immunoglobulin M(IgM),Immunoglobulin G(IgG) Immunoglobulin A(IgA)] and intestinal mucosal barrier [blood vessels] between the two groups of patients Endothelial growth factor(Vascular endothelial growth factor,VEGF),transforming growth factor-β1(Ttansforming Growth Factor-β1,TGF-β1),plasma endotoxin content,urinary lactulose/mannitol ratio] and adverse reactions.Results:After 8 weeks of treatment,the levels of IgG,IgA,and IgM in the observation group were higher than those in the control group(P<0.05);the endotoxin levels and urinary lactulose/mannitol ratio in the observation group were lower than those in the control group(P<0.05),and VEGF,TGF-β1 levels were lower than those in the control group(P<0.05);the total effective rate in the observation group was 63.41%,which was higher than 41.46% in the control group(P<0.05);cases of gastrointestinal reactions,peripheral neuropathy and abnormal liver function occurred in the observation group The numbers were lower than those in the control group(P<0.05).Conclusion:The application of Yichang Kangcan Recipe in the treatment of patients with colon cancer undergoing postoperative chemotherapy has obvious effects.It can improve the intestinal mucosal barrier function and immune function of patients,and reduce the adverse reactions caused by chemotherapy.It is worthy of clinical reference application.