恶性肿瘤相关性高钙血症影响因素与中医证型分析

Analysis of Influencing Factors of Hypercalcemia Associated with Malignant Tumors and TCM Syndrome Types

目的:分析恶性肿瘤相关性高钙血症的影响因素,为更好地预测和对症治疗提供依据。方法:研究符合标准的恶性肿瘤患者100例,其中相关性高钙血症患者与非高钙血症患者各50例,将二者分为高钙组与对照组。对2组之间相关因素的差异进行统计学分析,通过二元Logistic回归分析恶性肿瘤相关性高钙血症的独立影响因素。结果:高钙组和对照组在性别、年龄、血清磷浓度方面P>0.05,差异无统计学意义,在TNM分期、有无骨转移、有无肺转移、血清白蛋白质量浓度、血清球蛋白质量浓度、肌酐浓度、血红蛋白质量浓度方面P<0.05,差异具有统计学意义。肌酐浓度、血清白蛋白质量浓度是恶性肿瘤相关性高钙血症的独立影响因素,中医证型与高钙的严重程度有相关性。结论:通过该研究对恶性肿瘤相关性高钙血症患者临床资料的分析,提示有必要对恶性肿瘤晚期患者定期进行电解质的复查,以便早期识别并及时治疗高钙血症。

Objective:To analyze the influencing factors of malignant tumor-related hypercalcemia and provide basis for better prediction and symptomatic treatment.Methods:A total of 100 patients with malignant tumors who met the criteria were studied,including 50 patients with associated hypercalcemia and 50 patients with non-hypercalcemia.They were divided into a hypercalcemia group and a control group.Statistical analysis was performed on the differences in related factors between the 2 groups,and the independent influencing factors of malignant tumor-related hypercalcemia were analyzed by binary logistic regression.Results:P>0.05 in terms of gender,age,and serum phosphorus concentration between the high calcium group and the control group.There was no statistical significance in the differences in TNM stage,presence or absence of bone metastasis,presence or absence of lung metastasis,serum albumin mass concentration,and serum globulin in terms of mass concentration,creatinine concentration,and hemoglobin mass concentration,and the difference was statistically significant(P<0.05).Creatinine concentration and serum albumin mass concentration are independent influencing factors of malignant tumor-related hypercalcemia.Traditional Chinese medicine syndrome types are related to the severity of hypercalcemia.Conclusion:The analysis of clinical data of patients with malignant tumor-related hypercalcemia in this study suggests that it is necessary to conduct regular electrolyte reexamination in patients with advanced malignant tumors in order to early identify and treat hypercalcemia in a timely manner.