血清TNC、血压及空腹血糖与糖尿病周围神经病变及增殖性糖尿病视网膜病变的相关性

Relationship of Serum TNC,Blood Pressure and Blood Glucose with Diabetic Peripheral Neuropathy and Proliferative Diabetic Retinopathy

【目的】探讨血清腱生蛋白C(tenascin-C,TNC)、血压及空腹血糖(fasting blood glucose,FPG)与糖尿病周围神经病变(diabetic peripheral neuropathy,DPN)和增生性糖尿病视网膜病变(proliferative diabetic retinopathy,PDR)的相关性。【方法】选取2021年6月至2022年6月柳州市红十字会医院收治的122例2型糖尿病(type 2 diabetes,T2DM)患者,按有无DPN分为A组(不伴DPN的患者,n=75)和B组(伴DPN的患者,n=47);A组、B组根据是否伴PDR进一步分组,A组分为A1组(不伴PDR患者,n=23)和A2组(伴PDR患者,n=52),B组分为B1组(不伴PDR患者,n=31)和B2组(伴PDR患者,n=16)。采用酶联免疫分析法检测各组血清TNC水平,采用罗氏生化仪检测FPG,测量各组血压值,分析血清TNC、血压及FPG与DPN和PDR的相关性。【结果】A组和B组血清TNC、FPG及收缩压(stolic pressure,SBP)比较,差异均无统计学意义(均P>0.05);A组和B组舒张压(diastolic pressure,DBP)比较,差异有统计学意义(P<0.05)。A1组与A2组、B1组与B2组血清TNC水平及SBP、DBP比较,差异均无统计学意义(均P>0.05)。A1与A2血清FPG水平比较,差异无统计学意义(P>0.05),B1组和B2组FPG水平比较,差异有统计学意义(P<0.05)。DPN与TNC、SBP及DBP均无相关性(P>0.05),DPN与FPG呈正相关(P<0.05)。【结论】血清TNC水平与DPN、PDR及DPN伴PDR共同发病均无关。T2DM伴DPN患者血压高于不伴DPN患者,同时伴有DPN和PDR患者FPG水平显著高于伴DPN患者。临床医师应控制T2DM患者血压、血糖水平,以降低T2DM并发症发生率。

【Objective】To investigate the relationship of serum tenascin-C(TNC),blood pressure and blood glucose with diabetic peripheral neuropathy(DPN)and Proliferative diabetic retinopathy(PDR).【Methods】A total of 122 patients with type 2 diabetes(T2DM)admitted to Liuzhou Red Cross Hospital from June 2021 to June 2022 were selected and divided into group A(patients without DPN,n=75)and group B(patients with DPN,n=47)according to whether they had DPN or not.Group A and group B were further divided two sub-groups according to whether PDR was present.Group A was divided into group A1(patients without PDR,n=23)and group A2(patients with PDR,n=52),and group B was divided into group B1(patients without PDR,n=31)and group B2(patients with PDR,n=16).Serum TNC was detected by enzyme-linked immunoassay(ELISA),Fasting blood glucose(FPG)was measured by Roche biochemical analyzer,and blood pressure was measured in each group.【Results】There were no significant differences in serum TNC,FPG and systolic pressure(SBP)between group A and group B(all P>0.05).There was significant difference in diastolic pressure(DBP)between group A and group B(P<0.05).There were no significant differences in serum TNC levels,SBP and DBP values between group A1 and group A2,as well as between group B1 and group B2(all P>0.05).There was no significant difference in serum FPG level between group A1 and group A2(P>0.05),but there was significant difference in serum FPG level between B1 and B2 groups(P<0.05).There was no correlation of DPN with TNC,SBP and DBP(P>0.05),but there was a positive correlation between DPN and FPG(P<0.05).【Conclusion】Serum TNC level is not associated with DPN,PDR or DPN with PDR.Patients with DPN had higher blood pressure than those without DPN,and patients with both DPN and PDR had higher FPG than those with DPN and PDR alone.Clinicians should control blood pressure and blood sugar levels in patients with T2DM to reduce the incidence of T2DM complications.Clinicians should pay attention to timely treatment and control of blood pressure and blood sugar in T2DM patients to reduce the occurrence of T2DM complications.