超声E成像联合血清铁蛋白水平对非酒精性脂肪性肝病的早期诊断价值

Early Diagnostic Value of Ultrasound E Imaging Combined with Serum Ferritin Level in Nonalcoholic Fatty Liver Disease

【目的】探讨超声E成像联合血清铁蛋白(SF)水平对非酒精性脂肪性肝病(NAFLD)的早期诊断价值。【方法】回顾性分析2020年2月至2022年6月宝鸡高新医院收治的85例NAFLD患者(NAFLD组),依据NAFLD患者肝脂肪变性的严重程度分为轻度脂变组(n=26)、中度脂变组(n=38)和重度脂变组(n=21)。另选取同期在宝鸡高新医院体检的60例健康志愿者(健康组)。比较各组患者临床资料、杨氏模量值及SF水平,分析NAFLD发生的影响因素及杨氏模量值、SF对NAFLD的早期诊断效能。【结果】NAFLD组体重指数(BMI)、空腹血糖(FPG)、总胆固醇(TC)、甘油三酯(TG)、杨氏模量值、SF水平高于健康组(P<0.05)。重度脂变组杨氏模量值、SF水平高于轻度脂变组和中度脂变组(P<0.05);中度脂变组杨氏模量值、SF水平高于轻度脂变组(P<0.05)。多因素分析结果显示:BMI、杨氏模量值及SF均为NAFLD发生的影响因素(P<0.05)。受试者工作特征(ROC)曲线的分析结果显示:杨氏模量值、SF及两者联合对NAFLD早期诊断的灵敏度分别为76.47%、78.82%、75.29%,特异度分别为71.67%、68.33%、96.67%,AUC分别为0.734、0.714、0.901。【结论】NAFLD的发生与BMI、杨氏模量值及SF水平有关,且超声E成像联合SF水平对NAFLD的早期诊断价值较高。

【Objective】To investigate the early diagnostic value of ultrasound E-imaging combined with serum ferritin(SF)level in nonalcoholic fatty liver disease(NAFLD).【Methods】A retrospective analysis was performed on 85 NAFLD patients admitted to our hospital from February 2020 to June 2022 and 60 healthy volunteers who received physical examinations in our hospital during the same period.They were selected and recorded as the NAFLD group and the healthy group,respectively.According to the severity of hepatic steatosis,NAFLD patients were further divided into three subgroups:mild steatosis group(26 cases),moderate steatosis group(38 cases)and severe steatosis group(21 cases).Young's modulus values were determined by ultrasound E-imaging in all subjects,and SF levels were detected by radioimmunoassay.The clinical data,Young's modulus value and SF level of the two groups were compared.The values of Young's modulus and SF levels in patients with NAFLD with different degrees of hepatic steatosis were compared as well.The related factors affecting the incidence of NAFLD were analyzed to reveal the early diagnosis value of Young's modulus value,SF and the combination of the two in predicting NAFLD occurrence.【Results】The levels of body mass index(BMI),fasting blood glucose(FPG),total cholesterol(TC),triglyceride(TG),Young's modulus and SF in the NAFLD group were higher than those in the healthy group(P<0.05).Young's modulus value and SF level in severe steatosis group were higher than those in mild steatosis group and moderate steatosis group(P<0.05).The Young's modulus value and SF level in the moderate steatosis group were higher than those in the mild steatosis group(P<0.05).The results of multivariate analysis showed that BMI,Young's modulus and SF were the influencing factors affecting the occurrence of NAFLD(P<0.05).The results of ROC curve analysis showed that the sensitivity of Young's modulus value,SF and their combination for early diagnosis of NAFLD was 76.47%,78.82%and 75.29%,respectively;The specificity was 71.67%,68.33%and 96.67%,respectively;And their AUC were 0.734,0.714 and 0.901,respectively.【Conclusion】The occurrence of NAFLD is related to BMI,Young's modulus value and SF level.Ultrasound E-imaging combined with SF level is of high value in the early diagnosis of NAFLD.