胃癌患者肌少症风险筛查和评估的最佳证据总结

Summary of best evidence for screening and evaluating the risk of sarcopenia in gastric cancer patients

目的收集国内外胃癌患者肌少症风险筛查和评估的最佳证据,为胃癌患者肌少症筛查及准确评估提供指导。方法计算机检索UpToDate、BMJ最佳临床实践、澳大利亚乔安娜布里格斯研究所循证卫生保健中心数据库、国际指南图书馆、中国医脉通指南网、英国国家临床医学研究所、Cochrane Library、加拿大安大略注册护士协会网站、PubMed、Embase、中华医学会老年医学分会、中国知网、万方数据知识服务平台和中国生物医学文献数据库中胃癌患者肌少症风险筛查和评估的相关文献,检索时限为建库至2023年9月1日。由2名经过循证知识培训的研究者独立进行文献筛选和质量评价,对符合要求的文献进行证据提取、总结。结果共纳入18篇文献,其中指南4篇、专家共识5篇、系统评价4篇、诊断性研究5篇。总结的最佳证据包括胃癌患者肌少症发生的危险因素、筛查时机、筛查内容、评估内容以及诊断标准与分期5个方面共18条最佳证据。结论汇总证据为提高胃癌患者肌少症风险筛检准确性提供了循证依据,医护人员可参考本研究总结的最佳证据,结合临床实际与胃癌患者的特点,合理地选择证据。

Objective To collect the best evidence for screening and evaluation of sarcopenia risk of gastric cancer patients at home and abroad,and to provide guidance for screening and accurate evaluation of gastric cancer sarcopenia patients.Methods The computer was used to search literature related to screening and evaluation of sarcopenia risk of gastric cancer patients in UpToDate,BMJ Best Clinical Practice,Australia Joanna Briggs Institute Evidence-based Health Care Centre Database,International Guide Library,China Medlive Guideline network,National Institute for Health and Clinical Excellence,Cochrane Library,Registered Nurses'Association of Ontario,PubMed,Embase,Geriatrics Branch of the Chinese Medical Association,China National Knowledge Infrastructure,Wanfang and China Biology Medicine disc.The search time was from database establishment to September 1,2023.Literature selection and quality evaluation were conducted independently by two researchers with evidence-based knowledge training,and evidence extraction and summary were carried out for literatures meeting the requirements.Results A total of 18 literatures were included,including four guidelines,five expert consensus,four systematic reviews and five diagnostic studies.The best evidence summarized included a total of 18 best evidence from 5 aspects,such as risk factors of sarcopenia in gastric cancer patients,screening time,screening content,evaluation content,diagnostic criteria and staging.Conclusions The summary of evidence provides evidence-based evidence for improving the accuracy of risk screening for gastric cancer sarcopenia patients.Medical staff can refer to the best summary of this study,combine clinical practice with the characteristics of gastric cancer patients and choose evidence reasonably.