SLC7A11的调控机制及其在心血管疾病中的作用

The regulatory mechanism of SLC7A11 and its roles in cardiovascular diseases

溶质载体家族7成员11(solute carrier family 7 member 11,SLC7A11/xCT)作为一种胱氨酸/谷氨酸逆向转运蛋白,参与氨基酸在质膜上的转运,调节细胞铁死亡的发生机制。近年来,越来越多的研究表明,SLC7A11与心血管系统疾病的发生、发展密切相关。本文综述了SLC7A11的结构、功能、调控机制及其在心血管疾病发展中的作用机理,旨在寻找与心血管疾病防治相关的潜在靶点。

The solute carrier family 7 member 11(SLC7A11/xCT)serves as a reverse transporter for cystine/glutamic acid,playing a crucial role in amino acid transportation across the plasma membrane.Additionally,it regulates the mechanism of ferroptosis within cells.In recent years,researches have demonstrated the close association between SLC7A11 and the occurrence and progression of cardiovascular disease.This review aims to explore the structure,function,and regulatory mechanisms of SLC7A11,while also examines its impact on the development of cardiovascular diseases.The ultimate objective is to identify potential targets that can be targeted for the prevention and treatment of cardiovascular diseases.