反义lncRNA在NSCLC中的作用及机制

The roles and mechanisms of antisense IncRNA in NSCLC

非小细胞肺癌(non-small cell lung cancer,NSCLC)在我国发病率和死亡率非常高,严重威胁着公众健康。由于缺乏敏感有效的早期诊断指标、易复发、易产生耐药性等因素,NSCLC的临床治疗效果一直不佳,导致患者预后差及生存率低。反义长链非编码RNA(long non-coding RNA,lncRNA)的异常表达与NSCLC发生发展密切相关,在NSCLC的增殖、凋亡、侵袭、迁移、上皮-间充质转化(epithelial-mesenchymal transition,EMT)和耐药等方面均发挥着重要作用,已成为近年来的研究热点。本文探讨反义lncRNA在NSCLC发生发展过程中的功能及具体调控机制,旨在为NSCLC患者提供更有效的治疗理论参考。

Non-small cell lung cancer(NSCLC)has a very high incidence and mortality rate in China,which seriously threatens public health.Due to the lack of sensitive and effective early diagnosis indicators,easy recurrence,easy to develop drug resistance and other factors,the clinical treatment effect of NSCLC is not effective,resulting in low survival rate and poor prognosis.The abnormal expression of antisense long noncoding RNA(lncRNA)is closely related to the occurrence and development of NSCLC,and plays an important role in the proliferation,apoptosis,invasion,migration,epithelial-mesenchymal transformation(EMT)and drug resistance of NSCLC,and has become a research hotspot in recent years.It is of great significance to explore the function and specific regulatory mechanism of antisense lncRNA in the process of NSCLC occurrence and development,which is of great significance to provide more effective treatment methods forNSCLC patients.