铜死亡在代谢相关脂肪性肝病中的作用

Roles of copper death in metabolism-related fatty liver disease

铜死亡是一种由二价铜离子过量引起的调节性细胞死亡形式。代谢相关脂肪性肝病是一种复杂的肝损疾病,由多系统代谢功能紊乱引起。铜离子过量会导致肝组织脂肪变性和肝功能紊乱,而且高浓度的铜会促使代谢相关脂肪性肝病向肝硬化甚至肝细胞癌的方向发展。铜死亡机制还会影响到机体内其他的细胞死亡进程,如铁死亡,从而干扰代谢相关脂肪性肝病的进展。本文就铜死亡在代谢相关脂肪性肝病中的作用进行综述,并对铜死亡相关治疗药物予以汇总和展望。

Cuproptosis is a form of regulatory cell death caused by excessive bivalent copper ions.Metabolism-associated fatty liver disease is a complex disease caused by multiple metabolic disorders.Excessive copper ion will lead to hepatic steatosis and liver dysfunction,and high concentrations of copper will promote the development of metabolism-related fatty liver disease to liver cirrhosis and even hepatocellular carcinoma.The mechanism of cuproptosis will also affect the process of other cell death in the body,such as ferroptosis,thus interfering with the progression of metabolism-related fatty liver disease.In this paper,the roles of cuproptosis in metabolism-related fatty liver disease were reviewed,and the therapeutic drugs related to cuproptosis were summarized and prospected.