肿瘤抗原相关自身抗体的产生机制及其在肿瘤中的作用

Tumor related antigen autoantibodies generation mechanism and its role in tumor

肿瘤抗原相关自身抗体在肿瘤诊断、临床应用方面的价值是目前研究的重点。它不仅可以作为肿瘤早期诊断的生物标记,也可监测治疗效果、判断预后,但目前关于肿瘤抗原相关自身抗体产生机制的研究较少,深入研究其产生机制是阐明肿瘤抗原相关自身抗体促肿瘤或抑肿瘤作用的前提,也是今后研究的重点之一。本文就近年来肿瘤抗原相关自身抗体的产生机制、肿瘤早期诊断及其在肿瘤发生发展和预后中的应用进行总结,为积极寻找特异性强、灵敏度高的肿瘤抗原相关自身抗体及检测组合,明确肿瘤抗原相关自身抗体在不同肿瘤中的意义提供一定的理论参考。

The current research focus is on the diagnostic and clinical application of tumor antigen related autoantibodies.They can be used not only as biomarkers for early diagnosis of tumors,but also to monitoring the treatment effects and determining prognosis.However,there are limited research with the production mechanism of tumor antigen related autoantibody,and in-depth study of the production mechanism is a prerequisite for elucidating the tumor-promoting or tumor-suppressing effects of tumor antigen related autoantibodies,which is also one of the focuses for future research.This review summarizes the mechanism of tumor antigen related autoantibody production,early tumor diagnosis,their roles of tumor development and prognosis in recent years.It provides a theoretical reference with actively searching for tumor antigen related autoantibodies,detection combinations with strong specificity and sensitivity,clarifying the significance of tumor antigen related autoantibodies in different tumors.