聚巴士比酸氯胺化合物的制备及生物活性

Preparation and Bioactivities of the Polymeric Chloramine Compound of the Barbituric Acid

采用苯乙烯、氯丙烯、二乙烯苯,通过悬浮聚合,合成高分子小球,高分子链上枝接巴士比酸,制备聚巴士比酸氯胺化合物前驱体。利用SEM和FTIR对其形貌及组成进行表征。通过反应物比例、反应pH值等条件优化,制备了中空和纳米级两种抗菌小球,发现液体石蜡可调节抗菌材料的粒径和孔径大小,二乙烯苯的加入量可调节抗菌材料的表面形态。在NaCl的存在下,在pH=1时,最高产率达到95%。新型的抗菌小球对大肠杆菌(E coli)和金黄色葡萄球菌(S aureus)具有较好的抑制作用,纳米小球在20 mg/mL时对106~107 CFU/mL的E coli和S aureus的杀灭率均达到100%。在50 mg/mL中空小球杀灭率达到99%以上。

Polymer pellets were synthesized by suspension copolymerization of styrene,chlorine propylene and diethylene benzene.The chloramine compound precursor was prepared by grafting barbituric acid on the polymer chain.The antibacterial pellets were characterized by SEM and FTIR.Two antibacterial beads of porous and nanoscale were prepared by optimization of reactant ratio and pH.It is found that the atolin can regulate the particle and aperture size of the antibacterial material,and diethylene benzene can adjust the surface morphology of the antibacterial material.In the presence of NaCl,the antibacterial material reached the high yield of 95%at pH=1.The nanospheres had good inhibition on Escherichia coli(E.coli)and staphylococcus aureus(S.aureus).The killing rate of E.coli and S.aureus on 106~107CFU/mL was up to 100%at 20 mg/ml.In 50 mg/mL,the killing rate ofantibacterial beads reached more than 99%.