血红素加氧酶1调控铁死亡对非酒精性脂肪性肝病的作用机制研究进展

Research progress on the mechanism of action of heme oxygenase-1 regulating ferroptosis in non-alcoholic fatty liver disease

非酒精性脂肪性肝病(NAFLD),已逐渐成为世界上流行率最高的慢性肝病,但其发病机制尚未完全阐明。铁死亡是一种由铁依赖性脂质过氧化引起的程序性细胞死亡新形式。血红素加氧酶1为公认的抗氧化酶,亦为铁死亡中重要的调节因子,可通过多种途径调节铁死亡进而调控NAFLD。现就血红素加氧酶1在铁死亡途径中对NAFLD的调控作用机制进行综述,以期探明NAFLD发生和发展机制,并为其防治问题提供新视野、新靶点。

Non-alcoholic fatty liver disease(NAFLD)has gradually become the most prevalent chronic liver disease in the world,but its pathogenesis has not been fully elucidated.Ferroptosis is a novel type of programmed cell death caused by iron-dependent lipid peroxidation.Heme oxygenase-1 is a recognized antioxidant enzyme and an important regulatory factor in ferroptosis that modulates ferroptosis through various pathways and,in turn,regulates NAFLD.This paper reviews the regulatory mechanism of heme oxygenase-1 on NAFLD in ferroptosis pathway,with a view to clarifying the occurrence and development mechanisms of NAFLD and providing new vision and targets for its prevention and treatment.