短链脂肪酸调节慢性肝病发病与转归的研究进展

Research progress in the regulation of pathogenesis and the transformation of chronic liver disease by short-chain fatty acids

短链脂肪酸是肠道菌群的代谢产物,作为主要能量来源为肠上皮细胞供能;同时作为重要的信号分子,通过受体依赖及非依赖的途径调控多种细胞炎症反应及增殖稳态。短链脂肪酸调控肠-肝轴,并借此直接作用于肝脏,参与包括酒精性肝病、代谢相关性肝病、自身免疫性肝病、肝纤维化、肝细胞癌在内多种肝脏疾病的发病及转归;此外短链脂肪酸可抑制HBV DNA复制。现就短链脂肪酸在慢性肝脏疾病发病及转归作用方面的研究进展进行综述。

Short-chain fatty acids are metabolites of the intestinal flora and serve as the main energy source for intestinal epithelial cells.At the same time,as important signaling molecules,it regulate a variety of cellular inflammatory responses and homeostatic proliferation through receptor-dependent and independent pathways.Short-chain fatty acids regulate the gut-liver axis and thereby directly act on the liver,participating in the pathogenesis and transformation of various liver diseases,including alcoholic liver disease,metabolic dysfunction-related liver disease,autoimmune liver disease,liver fibrosis,and hepatocellular carcinoma.In addition,short-chain fatty acids can inhibit HBV DNA replication.This article reviews the research progress on the role of short-chain fatty acids in aspects of the pathogenesis and transformation of chronic liver diseases.