广州地区259例丙型肝炎病毒患者HCV基因分型研究

A Study on HCV Genotypes of 259 Hepatitis C Virus Patients in Guangzhou Area

目的 了解广州地区丙型肝炎病毒患者的HCV基因型分布情况,为该地区丙型肝炎病毒的预防和诊疗提供依据。方法 选择自2019年9月至2023年4月共259例丙型肝炎病毒患者的HCV基因分型的结果,分析比较不同年龄、性别和年度各基因型感染率的差异。结果 共纳入259例患者,最常见的基因型为6a型和1b型,占42.47%和42.08%,与其他亚型差异有统计学意义(P<0.05)。其余依次为3a型占6.18%,2a型占4.63%,3b型占4.25%,2b型占0.39%,未发现亚型混合感染。1b型,青年人群(41.86%)、中年人群(31.447%)分别低于老年人群的71.93%;6a型,青年人群(44.186%)、中年人群(51.572%)分别高于老年人群的15.789%,差异有统计学意义(P<0.05)。女性1b型63.077%、2a型10.769%分别高于男性的35.052%和2.577%,女性6a型18.462%低于男性的50.516%,差异有统计学意义(P<0.05)。不同年度各基因型感染率差异无统计学意义。结论 广州地区丙型肝炎病毒患者HCV基因分型以6a型、1b型为主。1b型多见于60岁以上的老年人群和女性,6a型多见于中青年人群及男性。

Objective To understand the distribution of HCV genotypes in patients with hepatitis C virus in Guangzhou area,and to provide a knowledge basis for the prevention and treatment of hepatitis C virus.Methods We obtained the results of HCV genotypes of 259 hepatitis C virus patients from September,2019 to April,2023,and compared positive rates of various genotypes across different age,gender groups and years.Results A total of 259 patients were included and the most common genotypes were 6a and 1b,accounting for 42.47%and 42.08%respectively.There were statistically significant differences when compared with other subtypes(P<0.05).Following these genotypes,others were 3a(6.18%),2a(4.63%),3b(4.25%)and 2b(0.39%).No mixed infection was found.The positive rates of 1b in young people(41.86%)and middle-aged people(31.447%)were lower than that of 71.93%in the elderly.The positive rates of 6a in young people(44.186%)and middle-aged people(51.572%)were higher than that of 15.789%in the elderly,with statistical differences.The positive rates of 1b(63.077%)and 2a(10.769%)in females were higher than that of 35.052%and 2.577%in males,respectively.The positive rates of 6a in females(18.462%)were lower than that of 50.516%in males,with statistical differences.There was no statistical difference between different years.Conclusion HCV genotypes of hepatitis C virus patients in Guangzhou area are mainly 6a and 1b.1b is more common in elderly people and female.6a is the predominant genotype among young and middle-aged population and males.