梓醇在神经退行性疾病中的神经保护作用研究进展

Research advances in the neuroprotective effect of catalpol in neurodegenerative diseases

神经退行性疾病(如阿尔茨海默病和帕金森病),其病理特征是神经元进行性丧失。神经退行性疾病常见于老年人,且发病率逐年上升,给社会及家庭带来沉重负担。梓醇是一种中草药内提取的活性成分,大量的体内外实验研究已证实,梓醇具有抗炎、抗氧化、抗细胞凋亡、促血管生成及神经保护等多种功能,对神经退行性疾病有显著的防治作用,梓醇可能成为一种较理想的神经退行性疾病治疗药物。因此,该文在此基础上就梓醇在神经退行性疾病的作用机制进行综述。

Neurodegenerative diseases,such as Alzheimer´s disease and Parkinson´s disease,are characterized by the progressive loss of neurons and are mainly observed in the elderly.The incidence rate of neurodegenerative diseases is increasing year by year,which brings heavy burden to the society and families.Catalpol is an active ingredient extracted from Chinese herbal medicine,and a large number of experimental studies in vivo and in vitro have confirmed that catalpol has various functions such as anti-inflammatory,antioxidant,anti-apoptosis,angiogenesis-promoting,and neuroprotective functions and plays an important role in the prevention and treatment of neurodegenerative diseases.Therefore,catalpol may become an ideal therapeutic drug for neurodegenerative diseases.This article reviews the mechanism of action of catalpol in neurodegenerative diseases.