氟马西尼在全身麻醉术后高龄患者催醒方面的作用分析

Analysis on role of flumazenil in awakening after general anesthesia in advanced age patients

目的分析氟马西尼在全身麻醉(简称全麻)术后高龄患者催醒方面的作用。方法选取2020年10月至2021年12月该院收治的60例全麻手术患者作为研究对象,采用抽签法将其分为对照组和观察组,每组30例。对照组患者催醒采用生理盐水,观察组患者催醒采用氟马西尼,比较两组患者注射后神经敏感程度、清醒程度、不良反应、催醒效果。结果两组注射后0~<10 min的神经敏感程度及清醒程度比较,差异无统计学意义(P>0.05),观察组患者注射10、20、30 min后神经功能敏感程度与清醒程度优于对照组,差异有统计学意义(P<0.05)。两组患者的不良反应发生率比较,差异无统计学意义(P>0.05)。观察组的催醒效果优于对照组,差异有统计学意义(P<0.05)。结论氟马西尼在高龄患者全麻术后的应用,可以提高其神经功能敏感程度,使其更快清醒,未增加不良反应,具有显著的催醒效果。

Objective To analyze the role of flumazenil in awakening after general anesthesia in the advanced age patients.Methods Sixty patients with general anesthesia admitted in this hospital from October 2020 to December 2021 were selected as the research subjects and divided into the control group and observation group by the lottery method,30 cases in each group.The patients in the control group adopted normal saline for awakening,and the patients in the observation group adopted flumazenil for awakening.The neural sensitivity degree,lucidity degree,adverse reactions and wake-up effects after injection were compared between the two groups.Results There was no statistically significant difference in nerve sensitive degree and lucidity degree at 0-10 min after injection between the two groups(P>0.05).The nerve function sensitivity degree and lucidity degree at 10,20,30 min after injection in the observation group were superior to the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence rate of adverse reactions between the two groups(P>0.05).The wake-up effect of the observation group was superior than that of the control group,the difference was statistically significant(P<0.05).Conclusion The application of flumazenil after general anesthesia in advanced age patients could increase their nervous function sensitivity,make them wake up faster without increasing adverse reactions,and has a significant wake-up effect.