熊果酸介导HIF-1α缓解木质化鸡胸肉发生的潜在作用机制研究

Study on Ursolic Acid Mediated Hypoxia Inducible Factor 1αPotential Mechanisms for Alleviating the Occurrence of Woody Breast

木质化鸡胸肉在快大型白羽肉鸡的胸肌组织中病变率高达20%,严重降低消费者的购买欲,也不利于后期加工,造成的经济损失相对较高。缺氧是导致木质化鸡胸肉发生的重要原因,缺氧诱导因子1α(HIF-1α)是机体缺氧状态下调节细胞功能的关键因子,缺氧会造成HIF-1α过表达,导致机体氧化应激、糖代谢紊乱和炎症反应的发生,进而导致快大型白羽肉鸡罹患木质化鸡胸肉。熊果酸具有抗氧化、抗炎和调节糖代谢等功效,并可通过腺苷酸激活蛋白激酶(AMPK)、磷脂酰肌醇3激酶/蛋白激酶B(PI3K/Akt)等信号通路调节HIF-1α在机体中的表达。作者综述了缺氧所导致的木质化鸡胸肉的发病机理以及熊果酸调控HIF-1α对氧化应激、糖代谢和炎症反应的影响,进一步分析了熊果酸通过AMPK、PI3K/Akt等信号通路调控HIF-1α缓解木质化鸡胸肉发生的潜在作用机制。

The lesion rate of woody breast is as high as 20%in fast-growing White feather broiler,it seriously reduces consumers’desire to buy,and is not conducive to post-processing,resulting in relatively high economic losses.Hypoxia is an important cause of woody breast,and hypoxia inducible factor 1α(HIF-1α)is a key factor in regulating cell function under hypoxia.Ursolic acid has the effects of anti-oxidation,anti-inflammatory and regulating glucose metabolism,and can regulate the expression of HIF-1αthrough adenylate-activated protein kinase(AMPK)and phosphatidylinositol kinase-3 kinase-protein kinase B(PI3K/Akt)signaling pathways.Therefore,the author reviews the pathogenesis of woody breast caused by hypoxia and how HIF-1αmediated glucose metabolism,oxidative stress and inflammatory responses are regulated by ursolic acid,and further analyzes the potential mechanism of ursolic acid regulating HIF-1αto alleviate the occurrence of woody breast through AMPK,PI3K/Akt and other signaling pathways.