戊型肝炎的实验室诊断指标与临床应用

Laboratory diagnosis and clinical applications of hepatitis E

戊型肝炎病毒(HEV)感染引起的戊型肝炎已成为我国最主要的急性病毒性肝炎之一。近年来HEV各检测指标, 包括HEV RNA、HEV抗原、抗-HEV IgM及抗HEV-IgG等指标, 在方法学上有了新进展及在实验室诊断中有了新发现。急性戊型肝炎患者、慢性戊型肝炎患者、肝外临床症状患者诊断以及病原体携带者、相关职业体检人员检测等不同人群中应进行多指标联合诊断。不同人群各指标检测结果有各自的临床意义。

Hepatitis E virus(HEV)is the major pathogen responsible for acute viral hepatitis in China.Recently,there have been new advances in the methodologies and novel discoveries in the laboratory diagnosis of HEV,including various diagnostic markers such as HEV RNA,HEV antigen,anti-HEV IgM,and anti-HEV IgG.A multi-indicator diagnostic approach should be applied across different populations,including patients with acute or chronic hepatitis E,individuals with extra-hepatic clinical symptoms,asymptomatic carriers,and specific occupational groups undergoing health assessments.The clinical significance of test results for each marker varies among these different groups.