新型冠状病毒抗原性变异和血清分型研究进展

Advances in the antigenic variation and serotype classification of SARS-CoV-2

当前,SARS-CoV-2各变异株之间交叉中和活性的下降提示出现不同的血清型。对病毒进行血清分型是多价/广谱疫苗研究的重要参考依据,也是疫情防控的重要指导。近日已有文献基于血清中和数据对SARS-CoV-2的抗原性分化和血清分型进行了研究和讨论。因此,本文对SARS-CoV-2血清分型的必要性、最新进展和重要价值进行综述。

The diminishing cross-neutralization activity among SARS-CoV-2 variants indicates that distinct serotypes of SARS-CoV-2 have emerged.Understanding the viral serotypes is crucial for the development of multivalent/broad-spectrum vaccines and serves as a pivotal guide for epidemic prevention and control.Recent literatures have discussed the antigenic differentiation and serotyping of SARS-CoV-2 based on serum neutralization data.Therefore,this review aims to provide an overview of the necessity,recent advances and the significance of SARS-CoV-2 serotype classification.