烟草烟雾通过HMGB1-RAGE途径促进慢性阻塞性肺疾病的发生发展

Development of Chronic Obstructive Pulmonary Disease Induced by Cigarette Smoke through HMGB1-RAGE Pathway

慢性阻塞性肺疾病(COPD)是一种以进行性气流阻塞为特征的慢性气道疾病。COPD由基因与环境共同作用所致,而烟草烟雾(CS)是COPD发生的主要环境危险因素。CS可通过影响高迁移率族蛋白B1(HMGB1)-晚期糖基化终末产物受体(RAGE)轴导致气道炎症、氧化应激和蛋白酶-抗蛋白酶失衡,最终促进COPD的发生发展。因此,深入研究HMGB1-RAGE途径相关COPD生物标志物可帮助筛查吸烟者中的COPD高危患者,提高COPD早期诊断率。

Chronic obstructive pulmonary disease(COPD)is a chronic airway disease characterized by progressive airflow obstruction.COPD is caused by a combination of genetic and environmental interactions,and cigarette smoke(CS)is a major environmental risk factor for COPD.CS causes airway inflammation,oxidative stress and protease-antiprotease imbalance by affecting the high mobility group box 1 protein(HMGB1)-advanced glycation end product receptor(RAGE)axis,which ultimately contributes to the development of COPD.Therefore,an in-depth study of COPD biomarkers associated with the HMGB1-RAGE pathway could help to screen the smokers at high risk of COPD,and improve early diagnosis rate of COPD.