前列腺癌内分泌治疗后发生神经内分泌分化的研究进展

Research Progress of Neuroendocrine Differentiation after Endocrine Therapy for Prostate Cancer

绝大部分前列腺癌行内分泌治疗后会逐渐发展为去势抵抗性前列腺癌(CRPC)。其中,部分CRPC是因为前列腺癌产生神经内分泌分化(NED)所致,这部分患者最终发展为神经内分泌前列腺癌,此类前列腺癌对内分泌治疗产生耐药,对放化疗效果较差,预后极差。目前对于前列腺癌内分泌治疗后发生NED的确切原因及机制尚未完全明确,针对这一类前列腺癌的治疗仍较困难。未来对前列腺癌内分泌治疗后发生NED进行深入探索,可为延缓内分泌治疗后前列腺癌发生NED进而发展为CRPC提供新思路。

After endocrine therapy,most of prostate cancer will gradually develop into castration-resistant prostate cancer(CRPC).Among them,some cases of CRPC are due to the development of neuroendocrine differentiation(NED)by prostate cancer,which eventually develop into neuroendocrine prostate cancer.This type of prostate cancer is resistant to endocrine therapy,sees poor efficacy in radiotherapy and chemotherapy,and has a very poor prognosis.At present,the exact cause and mechanism of NED after endocrine therapy for prostate cancer are not completely clear,and it is still difficult to treat this kind of prostate cancer.In the future,in-depth exploration of the occurrence of NED in prostate cancer after endocrine therapy can provide new ideas for delaying the occurrence of NED and developing into CRPC.