免疫球蛋白和超敏C反应蛋白在小儿手足口病临床检验中的价值探讨

Discussion on the Value of Immunoglobulin and Hypersensitive C-reactive Protein in Clinical Detection of Children with Hand-Foot-Mouth Disease

目的 探讨免疫球蛋白和超敏C反应蛋白(hs-CRP)在小儿手足口病临床检验中的价值。方法 选择73例小儿手足口病患儿纳入观察组,另选择73名体检健康儿童纳入对照组。检测两组儿童的免疫球蛋白和hs-CRP水平,并绘制ROC曲线,评估各项指标单独检测与联合检测诊断手足口病的价值。结果 观察组IgG、 IgA低于对照组,IgM、 hs-CRP高于对照组(P<0.05)。联合检测诊断小儿手足口病的AUC为0.914,高于各项指标单独检测(P <0.05)。联合检测诊断小儿手足口病的灵敏度、特异度与准确率均高于各项指标单独检测(P <0.05)。结论 手足口病患儿存在免疫屏障损伤和炎性反应,免疫球蛋白与hs-CRP会出现异常改变,临床对上述指标进行联合检测可提高小儿手足口病的诊断准确率,便于指导后续治疗。

Objective To explore the value of immunoglobulin and hypersensitive C-reactive protein(hs-CRP)in clinical detection of children with hand-foot-mouth disease.Methods 73 children with hand-foot-mouth disease were selected as the observation group,while 73 healthy children with physical examination during the same period were selected as the control group.The immunoglobulin and hs-CRP levels of both groups were detected.ROC curve was drawn to evaluate the value of single and combined detection in the diagnosis of hand-foot-mouth disease.Results The IgG and IgA of the observation group were lower than those of the control group,while the IgM and hs-CRP were higher than those of the control group(P<0.05).The AUC of the combined detection in the diagnosis of hand-foot-mouth disease in children was 0.914,higher than that of single detection(P<0.05).The sensitivity,specificity,and accuracy of the combined detection in the diagnosis of hand-foot-mouth disease in children are higher than those of single detection(P<0.05).Conclusions Children with hand-foot-mouth disease have immune barrier damage and inflammatory reactions,and abnormal changes in immunoglobulin and hs-CRP may occur.The combined detection of above indicators in clinic can improve the diagnostic accuracy of children with hand-foot-mouth disease and facilitate guidance for subsequent treatment.