甲磺酸酚妥拉明联合硝苯地平及硫酸镁治疗妊娠高血压综合征的临床效果观察

Observation on the Clinical Effect of Phentolami ne Mesylate Combined with Nifedipine and Magnesium Sulfate in the Treatment of Patients with Pregnancy-Induced Hypertension Syndrome

目的 观察甲磺酸酚妥拉明联合硝苯地平及硫酸镁治疗妊娠高血压综合征的临床效果。方法选取2021年4月至2022年4月我院收治的98例妊娠高血压综合征患者,随机分为两组各49例。对照组采用硫酸镁治疗,观察组在对照组基础上采用甲磺酸酚妥拉明联合硝苯地平治疗,均连续治疗7 d。比较两组的治疗效果、血压及不良妊娠结局。结果 观察组治疗总有效率为95.92%,高于对照组的79.59%(P <0.05)。治疗7 d后,两组收缩压、舒张压均低于治疗前,且观察组收缩压、舒张压均低于对照组(P <0.05)。观察组不良妊娠结局发生率为8.16%,低于对照组的26.53%(P <0.05)。结论 甲磺酸酚妥拉明联合硝苯地平及硫酸镁治疗妊娠高血压综合征,可明显提升临床疗效,降低患者血压和不良妊娠结局发生风险。

Objective To observe the clinical effect of phentolamine mesylate combined with nifedipine and magnesium sulfate in the treatment of patients with pregnancy-induced hypertension syndrome.Methods 98 patients with pregnancy-induced hypertension syndrome admitted to our hospital from April 2021 to April 2022 were randomly divided into two groups equally.The control group was treated with magnesium sulfate,and the observation group was treated with phentolamine mesylate combined with nifedipine on the basis of the control group.Both groups were treated continuously for 7 days.The treatment effect,blood pressure and adverse pregnancy outcomes were compared between the two groups.Results The total effective rate of treatment in the observation group was 95.92%,higher than 79.59% in the control group(P<0.05).After 7 days of treatment,the systolic and diastolic blood pressure of both groups were lower than those before treatment,and the systolic and diastolic blood pressure of the observation group were lower than those of the control group(P<0.05).The incidence of adverse pregnancy outcomes in the observation group was 8.16%,lower than 26.53% in the control group(P<0.05).Conclusions Phentolamine mesylate combined with nifedipine and magnesium sulfate in the treatment of pregnancy-induced hypertension can significantly improve clinical efficacy,reduce the blood pressure levels and the risk of adverse pregnancy outcomes.