子宫内膜异位症相关生物标志物研究进展

Research progress on biomarkers related to endometriosis

子宫内膜异位症(EMs)其特征是子宫腔外存在子宫内膜样组织,是育龄期妇女常见的一种慢性良性易复发疾病,全球发病率约为10%。由于该病是一种多因素疾病,发病机制未阐明,目前诊断金标准仍为腹腔镜病理检查,临床上缺少敏感且特异的生物标志物,寻找准确可靠、适用于临床的无创生物标志物是当前研究的热点和重点。本文对与EMs相关的糖类蛋白、转录组学、自身抗体生物标志物中最重要、最新颖的研究结果进行总结,为早期诊断、靶向治疗提供新的策略。

Endometriosis(EMs),characterized by the presence of endometrioid tissue outside the uterine cavity,is a common chronic benign recurrent disease in women of childbearing age,with a global incidence rate of about 10%.Due to its multifactorial nature and unclear pathogenesis,the current diagnostic gold standard for this disease is still laparoscopic pathology.There is a lack of sensitive and specific biomarkers in clinical practice.Finding accurate,reliable,and applicable non-invasive biomarkers is currently a hot topic and focus of research.This article summarizes the most important and novel research results of EMs-related glycoproteins,transcriptomics,and autoantibody biomarkers,and provides new strategies for early diagnosis and targeted therapy.