外泌体调控肺癌肿瘤微环境机制和临床应用的研究进展

Advancements in the study of exosome-mediated regulation mechanisms of the tumor microenvironment and its clinical applications in lung cancer

肺癌发病率逐年上升,是目前癌症死亡的主要原因。外泌体是细胞分泌的内源性膜小囊泡,目前已被公认是细胞间遗传物质的转运载体,在不同细胞通讯间发挥桥梁作用。近年来,越来越多的研究数据表明外泌体携带的蛋白质、脂质、核酸(lncRNA、microRNA、mRNA)等遗传物质在肺癌肿瘤微环境中发挥重要作用。本文主要综述外泌体调控肺癌肿瘤微环境相关作用机制,探讨外泌体作为肿瘤药物递送载体和循环标志物在肺癌诊断和治疗评估的应用价值。

The incidence of lung cancer is increasing year by year,and it is currently the leading cause of cancerrelated deaths.Exosomes are endogenous membrane vesicles secreted by cells,and have been recognized as essential carriers of intercellular genetic materials,playing a bridging role in communication between different cells.In recent years,a growing body of research data have indicated that exosomes carrying genetic materials such as proteins,lipids,and nucleic acids(including lncRNA,microRNA,mRNA)play a significant role in the tumor microenvironment of lung cancer.This article mainly reviews the mechanisms of exosomes regulating the tumor microenvironment in lung cancer,and discusses the application value of exosomes as drug delivery vehicles and circulating biomarkers in the diagnosis and treatment evaluation of lung cancer.