循环肿瘤DNA在结直肠癌精准诊疗中的应用

Application of Circulating Tumor DNA in Precision Diagnosis and Treatment of Colorectal Cancer

结直肠癌(colorectal cancer,CRC)是世界上最常见的恶性肿瘤之一,其发病率和死亡率居高不下,严重危害着人们的身体健康。传统的诊断模式已不能满足现如今人们对于肿瘤进行实时监测的需求。对比传统的检测手段,ctDNA检测不仅无创,而且能够实时检测肿瘤全面的基因组信息。随着检测技术的进步,逐渐凸显出其在CRC临床治疗中的潜在价值。本文就ctDNA在CRC患者中早期筛查、微小残留病变检测、指导个体化治疗的临床应用进展进行综述。

Colorectal cancer(CRC)is one of the most common malignant tumors recorded worldwide.This condition has high morbidity and mortality and seriously endangers people's health.Traditional diagnostic models fail to meet people's current needs for real-time monitoring of tumors.Compared with traditional detection methods,ctDNA detection is not only noninvasive but can also attain real-time detection of comprehensive genomic information of tumors.The advancement of detection technology has gradually highlighted the potential of ctDNA detection in the clinical treatment of CRC.This article reviews the advancements on the clinical application of ctDNA in early screening,minimal residual disease detection,and guidance on individualized treatment of CRC patients.