重复经颅磁刺激治疗对注意力缺陷伴多动障碍患儿临床疗效、认知功能及神经递质的影响

Effects of repeated transcranial magnetic stimulation on clinical efficacy,cognitive function and neurotransmitters in children with attention deficit and hyperactivity disorder

目的:分析重复经颅磁刺激(Repeat transcranial magnetic stimulation,rTMS)对注意力缺陷伴多动障碍患儿临床疗效、认知功能及神经递质的影响.方法:选择2020年5月-2023年1月于本院就诊治疗的注意力缺陷伴多动障碍患儿202例作为研究对象.根据治疗方案不同,将患儿分为对照组(99例)和观察组(103例).对照组采用药物治疗;观察组在对照组基础上采用rTMS治疗.分析比较两组的临床疗效,认知功能[Conners儿童行为量表、韦氏儿童智力量表(Wechsler Intelligence Scale for Children,WISC-Ⅳ)]、神经递质[脑源性神经营养因子(Brain-derived neurotrophic factor,BDNF)、神经元特异性烯醇化酶(Neuron-specific enolase,NSE)].结果:观察组的治疗总疗效显著高于对照组(P<0.05).观察组注意力缺陷、多动-冲动及对立违抗评分下降程度大于对照组(P<0.05).观察组Conners儿童行为量表评分低于对照组,WISC-Ⅳ评分均明显高于对照组(P<0.05).观察组BDNF水平高于对照组,NSE水平低于对照组(P<0.05).结论:rTMS治疗对注意力缺陷伴多动障碍患儿临床疗效具有提升效果,可有效改善认知功能,且调节BDNF、NSE水平.

Objective:To analyze the effect of Repeat transcranial magnetic stimulation(rTMS)on the clinical efficacy,cognitive function and neurotransmitters of children with attention deficit with hyperactivity disorder.Methods:202 children with attention deficit with hyperactivity disorder who were treated in our hospital from May 2020 to January 2023 were selected as the study objects.According to different treatment plans,the children were divided into control group(99 cases)and observation group(103 cases).The control group was treated with drugs.Observation group was treated with rTMS on the basis of control group.The clinical efficacy of the two groups was analyzed and compared.The cognitive function[Conners Child Behavior Scale,Wechsler Intelligence Scale for Children(Wcic-iv)],neurotransmitters[Brain-derived neurotrophic factor(BDNF),Neuron-specific enolase(NSE)].Results:The total therapeutic effect of the observation group was significantly higher than that of the control group(P<0.05).The attention-deficit,hyperactive-impulsivity and oppositional defiance scores in the observation group were significantly lower than those in the control group(P<0.05).The Conners behavior scale score of the observation group was lower than that of the control group,and the WISC-Ⅳscore was significantly higher than that of the control group(P<0.05).The level of BDNF in the observation group was higher than that in the control group,and the level of NSE was lower than that in the control group(P<0.05).Conclusion:rTMS therapy can improve the clinical effect of attention deficit with hyperactivity disorder,improve cognitive function,and regulate the levels of BDNF and NSE.