血清CysC水平与短暂性脑缺血发作患者颈内动脉狭窄的相关性

Correlation between serum CysC level and internal carotid artery stenosis in patients with transient ischemic attack

目的:探讨血清胱抑素C(Cystatin c,CysC)水平与短暂性脑缺血发作(Transient ischemic attack,TIA)患者颈内动脉狭窄的相关性.方法:纳入2019年1月至2022年6月我院收治的170例TIA患者为研究对象,根据脑血管造影检查结果评估颈动脉狭窄发生情况;并将颈动脉狭窄程度分为轻度狭窄组(n=38)、中度狭窄组(n=40)和重度狭窄组(n=41).收集所有患者基线资料,并在入院后测定患者实验室指标,重点分析血清CysC水平与TIA患者颈内动脉狭窄的相关性.结果:170例TIA患者中有119例患者发生颈动脉狭窄,发生率为70.00%,其中轻度狭窄患者38例,中度狭窄患者40例,重度狭窄患者41例;四组TIA患者性别、吸烟史、饮酒史、年龄、体重指数(Body Mass Index,BMI)、入院时美国国立卫生研究院卒中量表(National Institutes of Health Stroke Scale,NIHSS)评分、入院时收缩压(Systolic Blood Pressure,SBP)及入院时舒张压(Diastolic blood pressure,DBP)、血清总胆固醇(Cholesterol,CHO)水平比较,差异无统计学意义(P>0.05);重度狭窄组患者血清CysC水平均高于中度狭窄组及轻度狭窄组,三组间比较,差异有统计学意义(P<0.05).经Logistic回归分析显示,血清CysC水平升高是TIA患者颈动脉狭窄程度加重的风险因子(OR>1,P<0.05).结论:血清CysC水平与TIA患者颈内动脉狭窄密切相关,血清CysC水平升高会加重TIA患者颈内动脉狭窄程度.

Objective:To investigate the correlation between serum Cystatin c(CysC)level and internal carotid artery stenosis in patients with Transient ischemic attack(TIA).Methods:170 patients with TIA admitted to our hospital from January 2019 to June 2022 were included in the study,and the occurrence of carotid artery stenosis was evaluated according to the results of cerebral angiography.Carotid artery stenosis was divided into mild stenosis group(n=38),moderate stenosis group(n=40)and severe stenosis group(n=41).Baseline data of all patients were collected,and laboratory indicators of patients were measured after admission,focusing on the correlation between serum CysC level and internal carotid artery stenosis in TIA patients.Results:Among 170 TIA patients,119 patients had carotid artery stenosis,the incidence rate was 70.00%,including 38 patients with mild stenosis,40 patients with moderate stenosis,and 41 patients with severe stenosis.Gender,smoking history,drinking history,age,Body Mass Index(BMI),National Institutes of Health Stroke Scale at admission,Comparison of NIHSS score,Systolic Blood Pressure(SBP),Diastolic blood pressure(DBP)and serum total Cholesterol(CHO)levels on admission,There was no significant difference(P>0.05).The level of serum CysC in the severe stenosis group was higher than that in the moderate stenosis group and the mild stenosis group,and the difference was statistically significant(P<0.05).Logistic regression analysis showed that increased serum CysC level was a risk factor for increased carotid artery stenosis in TIA patients(OR>1,P<0.05).Conclusion:The level of serum CysC is closely related to internal carotid artery stenosis in TIA patients,and the increase of serum CysC level will aggravate the degree of internal carotid artery stenosis in TIA patients.