颅咽管瘤相关下丘脑性肥胖危险因素及饮食运动干预研究进展

Recent Advances in Diet and Exercise Interventions towards Craniopharyngioma-related Hypothalamic Obesity

颅咽管瘤相关下丘脑性肥胖已成为颅咽管瘤患者术后管理中的重要问题。有研究指出通过调整热量摄入、制订并实施运动计划能显著降低颅咽管瘤相关下丘脑性肥胖患者体质量,可将非药物治疗措施如饮食运动干预应用于颅咽管瘤患者的体质量管理中,但目前国内相关研究较少。因此,本文综述了颅咽管瘤相关下丘脑性肥胖现状、危害、危险因素和饮食运动干预策略,以期改善疾病预后、提高生存质量。建议临床医护人员应重视颅咽管瘤患者相关下丘脑性肥胖,开展颅咽管瘤相关下丘脑性肥胖患者体质量控制的前瞻性研究,并构建科学严谨的饮食运动干预方案,为全面提高颅咽管瘤患者的生存质量提供参考。

Craniopharyngioma-related hypothalamic obesity(CHO) has become a key issue in postoperative management of craniopharyngioma.Modified low calorie diet and exercise interventions have been found by some studies to be effective in relieving CHO,and suggested to be used as non-pharmacological treatments for weight management of craniopharyngioma patients.However,there are few relevant studies in China.We reviewed the latest developments in prevalence,hazards and risk factors as well as diet and exercise interventions towards CHO,in order to improve the outcomes and quality of life of CHO patients.In addition,we put forward recommendations on comprehensively improving the quality of life of CHO patients,such as making efforts to value CHO clinically,carrying out prospective studies on weight control in CHO,and developing rigorous diet and exercise interventions.