特瑞普利单抗免疫相关不良事件药学监护

Pharmaceutical care for immune-related adverse events induced by toripalimab

目的 探讨临床药师在特瑞普利单抗引起的免疫相关不良事件中的药学监护方式。方法 临床药师对1例患者使用特瑞普利单抗治疗后查出肾损伤、甲状腺功能减退及骨骼肌毒性的病例进行药学查房,通过不良反应关联性评价和机制分析,判断该患者很可能是由特瑞普利单抗引起的不良反应。结果 临床药师协助医生制定治疗方案、并对患者进行了全程化药学监护,取得良好效果。结论 临床药师在免疫相关不良事件的识别和管理中发挥重要作用,有效保障患者用药安全。

Objective To explore the pharmaceutical care approach of clinical pharmacists in immune-related adverse events caused by toripalimab.Methods A clinical pharmacist conducted a pharmacy checkup on a case in which renal injury,hypothyroidism and skeletal muscle toxicity were detected in a patient treated with toripalimab,and determined that the patient was most likely to have adverse reactions caused by toripalimab through the evaluation of the correlation of the adverse reactions and the analysis of the mechanism.Results A clinical pharmacist assisted the physician in formulating the treatment plan,and conducted full-scale pharmacological monitoring of the patient,achieving good results.Conclusion Clinical pharmacists play an important role in the identification and management of immune-related adverse events,effectively ensure the safety of medication.