托珠单抗注射液致过敏性休克1例分析

One case of allergic shock caused by tocilizumab injection

目的 分析托珠单抗注射液致过敏性休克的特点,为临床合理用药提供参考。方法 报道1例儿童使用托珠单抗导致过敏性休克的案例,通过文献回顾托珠单抗导致过敏性休克的情况,并分析原因及防治措施。结果 根据患者的临床表现及药物与用药时间的关联性,考虑托珠单抗导致过敏性休克,患者经有效抗过敏治疗后,过敏性休克症状得到缓解。结论 临床应用托珠单抗应警惕过敏性休克等过敏情况,对严重过敏患者应禁止使用。

Objective To analyze the characteristics of anaphylactic shock induced by tocilizumab injection in order to provide reference for clinical safe and rational drug use.Methods One case of anaphylactic shock caused by tocilizumab was analyzed.The related literature was reviewed while the causes,prevention and treatment of such adverse drug reactions were analyzed.Results According to the clinical manifestations of the patient and the correlation between the drug and the time of administration,this case of anaphylactic shock was considered to have been caused by tocilizumab.The symptoms of anaphylactic shock were relieved after effective anti-allergic treatment.Conclusion Clinicians should be wary of anaphylactic shock and other allergic conditions related to the use of tocilizumab,which should not be used in allergic patients.