盐酸羟考酮超前镇痛在肱骨骨折手术中的应用效果

Application Effect of Oxycodone Hydrochloride Preemptive Analgesia in Humeral Fracture Surgery

目的:探讨盐酸羟考酮对肱骨骨折手术患者疼痛感和血清细胞免疫因子水平的影响。方法:选取2020年4月—2022年1月本院骨科收治的73例肱骨骨折手术患者作为研究对象,根据用药方案的不同将患者分为试验组(n=38)和对照组(n=35)。对照组给予氟比洛芬酯,试验组给予盐酸羟考酮超前镇痛,比较两组炎症因子水平、免疫功能及疼痛程度。结果:两组术后24 h外周血中IL-6和TNF-α水平低于术前,且试验组低于对照组(P<0.05);两组术后24 h外周血中CD8^(+)低于对照组,CD4^(+)及CD4^(+)/CD8^(+)高于对照组(P<0.05);试验组术后2、4、6、12 h VAS疼痛评分均低于对照组(P<0.05)。结论:在骨科肱骨骨折手术的治疗中使用盐酸羟考酮超前镇痛能够有效缓解患者术后疼痛感,并改善患者的免疫功能,值得临床应用。

Objective:To investigate the effect of oxycodone hydrochloride on pain and serum cellular immune factors in patients with humeral fracture surgery.Methods:A total of 73 patients who underwent humeral fracture surgery in our hospital from April 2020 to January 2022 were selected as study subjects.The patients were divided into experimental group(n=38)and control group(n=35)according to different medication regimens.The control group was given flurbiprofen axetil,and the experimental group was given oxycodone hydrochloride preemptive analgesia.The levels of inflammatory factors,immune function and pain degree were compared between the two groups.Results:The levels of IL-6 and TNF-αin peripheral blood of the two groups at 24 h after operation were lower than those before operation,and the experimental group was lower than the control group(P<0.05).CD8+in peripheral blood of the two groups at 24 h after operation was lower than that of the control group,and CD4^(+)and CD4^(+)/CD8+were higher than those of the control group(P<0.05).The VAS pain scores of the experimental group at 2,4,6 and 12 h after operation were lower than those of the control group(P<0.05).Conclusion:The use of oxycodone hydrochloride preemptive analgesia in the treatment of orthopedic humeral fracture surgery can effectively relieve postoperative pain and improve the immune function of patients,which is worthy of clinical application.