参附注射液联合常规西医对尘肺病并肺源性心脏病的疗效及对其心肺功能的影响

Efficacy of Shenfu injection combined with conventional western medicine on pneumoconiosis complicated with chronic pulmonary heart disease and its impact on cardiopulmonary function

目的探讨参附注射液联合常规西医对尘肺病并肺源性心脏病的疗效及对其心肺功能的影响。方法选取2018年8月—2022年8月本院收治的60例尘肺病并肺源性心脏病患者作为研究对象,采用随机数表法分为研究组和对照组两组,每组各30例。对照组给予常规西医治疗,研究组给予参附注射液联合常规西医治疗,均治疗14 d。比较两组患者治疗前后临床症状评分、心肺功能、动脉血气分析指标,以及临床疗效和不良反应发生情况。结果治疗后两组临床症状积分、肺动脉收缩压(PASP)、右心室流出道(ROVT)内径、血氧分压(PaO_(2))均降低(P<0.05),右心室射血分数(RVEF)、用力肺活量(FVC)、第1秒用力呼气容积(FEV1)、第1秒用力呼气容积占用力肺活量比值(FEV1/FVC)、二氧化碳分压(PaCO_(2))、血氧饱和度(SaO_(2))均升高(P<0.05),且治疗后研究组临床症状积分、PASP、ROVT、PaO_(2)均低于对照组(P<0.05),RVEF、FVC、FEV1、FEV1/FVC、PaCO_(2)、SaO_(2)均高于对照组(P<0.05);研究组总有效率为93.33%,对照组为73.33%,组间差异具有统计学意义(P<0.05);研究组(10.00%)和对照组(16.67%)不良反应发生率比较,差异无统计学意义(P<0.05)。结论参附注射液联合常规西医治疗尘肺病并肺源性心脏病疗效显著,有效减轻了患者临床症状,改善患者心肺功能,安全性良好。

Objective To explore the efficacy of Shenfu injection combined with conventional western medicine in the treatment of pneumoconiosis complicated with chronic pulmonary heart disease and its effect on cardiopulmonary function.Methods Sixty patients suffering from pneumoconiosis and pulmonary heart disease who were admitted to our hospital from August 2018 to August 2022 were selected as study subjects,and they were divided into the study group(n=30)and the control group(n=30)according to random number table method.The control group was treated with conventional western medicine,while the study group was treated with Shenfu injection combined with conventional western medicine,and they were all treated for 14 days.The clinical symptom score,cardiopulmonary function and arterial blood gas analysis indexes before and after treatment,clinical efficacy and adverse reactions of the two groups were compared.Results After treatment,the clinical symptom score,pulmonary artery systolic pressure(PASP),right ventricular outflow tract(ROVT)diameter,blood oxygen partial pressure(PaO_(2))were decreased(P<0.05),and right ventricular ejection fraction(RVEF),the forced expiratory volume in the first second(FEV1),forced vital capacity(FVC),forced expiratory volume in the first second to forced vital capacity ratio(FEV1/FVC),partial pressure of carbon dioxide(PaCO_(2)),and oxygen saturation(SaO_(2))were increased(P<0.05).After treatment,the clinical symptom score,PASP,ROVT,and PaO_(2)in the study group were lower than those in the control group(P<0.05),while the RVEF,FVC,FEV1,FEV1/FVC,PaCO_(2),and SaO_(2)were higher than those in the control group(P<0.05).The total effective rate of the study group was 93.33%,and that of the control group was 73.33%,the difference between the two groups was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the study group(10.00%)and the control group(16.67%)(P>0.05).Conclusions Shenfu injection combined with conventional western medicine has a significant effect on pneumoconiosis complicated with chronic pulmonary heart disease,which can effectively reduce the clinical symptoms of patients,improve the cardiopulmonary function of patients,and it has good safety.