多病共存慢性病患者六分钟步行距离与肺功能及生活质量的相关性

Correlation of six-minute walking test with lung fuction and quality of life in patients with multimorbidity

目的 通过使用智能化六分钟步行试验(6MWT)设备测定多病共存慢性病患者的六分钟步行距离(6MWD),探讨6MWD与肺功能、生活质量、临床指标等方面的相关性。方法 选取2022年1月至12月在北京大学第三医院全科医学科住院的多病共存慢性病患者138例。测量6MWD,监测并记录试验前后患者肺功能,收集入选患者的一般资料、身高、体重、血常规[白细胞计数(WBC)、血红蛋白(Hb)、血小板计数(PLT)]、肝功能[白蛋白(ALB)、门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)]、肾功能[肌酐(Cr)、尿素氮(BUN)、尿酸(UA)]、糖代谢指标[空腹血糖(FPG)、糖化血红蛋白(HbA1c)]、血脂[三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)]、超声心动图指标[左室舒张末期内径(LAD)、E峰、A峰以及左室射血分数],并对入选患者进行SF-36量表测评,分析6MWD与上述指标的相关性。结果 138例患者中,2、3、4、5种疾病共存的患者分别为58例、47例、23例、10例。6MWD与身高、试验前后的肺功能[用力肺活量(FVC),第1秒用力呼气容积(FEV1),FEV1/FVC]、生理机能、生理职能、Hb、ALT、LDL-C分别呈正相关(P<0.05),与年龄、FPG、HbA1c、A峰分别呈负相关(P<0.05)。结论 6MWD与多病共存慢性病患者的心肺功能和生活质量具有相关性,6MWT可以在对多病共存慢性病患者整体功能的评估及监测方面发挥重要作用。

Objective To dectect six-minute walking distance(6MWD) of patients with multimorbidity by an intelligent six-minute walking test(6MWT) device,and to investigate the correlation of 6MWD with lung function,quality of life,and clinical indicators.Methods A total of 138 patients with multimorbidity who were hospitalized in the General Practice Department of Peking University Third Hospital from January to December 2022 were selected.6MWT was conducted in patients,and pulmonary function before and after the test was measured,and the general data,height,weight,blood routine [white blood cell(WBC) count,hemoglobin(Hb),platelet(PLT) count],liver function [albumin(ALB),aspartate aminotransferase(AST),alanine aminotransferase(ALT)],renal function [creatine(Cr),blood urea nitrogen(BUN),uric acid(UA)],carbohydrate metabolism indicators [fasting blood glucose(FPG),glycated hemoglobin(HbA1c)],blood lipids [total cholesterol(TC),triglycerides(TG),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C)],echocardiographic indicators [left ventricular end diastolic diameter(LAD),E peak,A peak,left ventricular ejection fraction] and SF-36 scores were collected.The correlations between 6MWD and the above indicators were analyzed.Results Among the 138 patients,58,47,23,and 10 patients coexisted with 2,3,4,5 diseases respectively.6MWD was positively correlated with height,pre-and post-test pulmonary function [forced vital capacity(FVC),forced expiratory volume in the first second(FEV1),FEV1/FVC],physical function,role-physical,Hb,ALT,LDL-C(P<0.05),and negatively correlated with age,FPG,HbA1c,and A-peak(P<0.05).Conclusion 6MWD is correlated with cardiovascular function and quality of life in patients with multimorbidity,and can play an important role in evaluating and monitoring the overall function of patients with multimorbidity.