非甾体抗炎药肠病肠黏膜屏障功能障碍研究及治疗进展

Research and treatment progress of intestinal barrier dysfunction in non-steroidal anti-inflammatory drugs enteropathy

肠黏膜屏障是由机械、化学、免疫和生物屏障共同构成的结构与功能的统一体,其作用是将肠腔内的物质与机体内环境隔离,维持机体内环境的稳定性。四层屏障具有相应的结构基础,通过发挥各自的生物学功能,在机体消化过程中以动态变化的形式选择性地吸收水和营养物质,同时防止肠道细菌异位,发挥免疫功能,有助于维持机体肠道的完整性和免疫稳定状态。非甾体抗炎药(NSAIDs)会通过改变体内多种炎症介质和病理过程损害肠道屏障而引起NSAIDs肠病的发生。本文综述了NSAIDs引起肠黏膜不同屏障功能损伤的机制和基于肠道菌群的防治进展,旨在为预防和治疗NSAIDs引起的小肠黏膜损伤寻找新的研究方向。

The intestinal mucosal barrier is a unified structure and function that maintains the stability of the internal environment of the organism,consisting of mechanical,chemical,immune,and biological barriers.Each barrier has corresponding structural foundations,which selectively absorb water and nutrients in a dynamically changing form during the body's digestion process by exerting their respective biological functions,preventing intestinal bacterial ectopia,exerting intestinal immune function,and assisting the body in maintaining intestinal integrity and immune homeostasis.Non-steroidal anti-inflammatory drugs(NSAIDs) can damage the intestinal barrier by altering various inflammatory mediators and pathological processes in the body.At present,studying intestinal barrier dysfunction has become a hot topic in the field of medical research.This article reviews the mechanism and prevention and treatment progress of intestinal mucosal barrier function damage caused by NSAIDs,aiming to provide reference for the prevention and treatment of intestinal mucosal damage caused by NSAIDs.