介入治疗在中晚期肝癌患者中的应用效果

Application effect of interventional therapy in patients with middle and advanced stage liver cancer

目的研究对中晚期肝癌患者实施介入治疗效果,为临床提供借鉴经验。方法选取2019年5月—2022年5月在滕州市中心人民医院受治疗的80例中晚期肝癌患者作为此次研究对象,采用随机数字表法分为常规治疗组和介入治疗组各40例。常规治疗组患者实施常规药物治疗,介入治疗组采取介入治疗。比较两组患者临床疗效、治疗前后肝功能指标(包括ALT、TBIL、AFP和ALB)以及治疗期间并发症发生率。结果介入治疗组治疗总有效率为95.00%,高于常规治疗组的75.00%,差异有统计学意义(χ^(2)=6.275,P<0.05)。治疗前,两组肝功能各项指标差异无统计学意义(P>0.05);治疗后,两组肝功能各项指标优于治疗前,且介入治疗组肝功能各项指标优于常规治疗组,差异均有统计学意义(P<0.05)。介入治疗组并发症发生率为7.50%,明显低于常规治疗组的27.50%,差异有统计学意义(χ^(2)=5.541,P<0.05)。结论相较于常规药物治疗而言,对中晚期肝癌患者实施介入治疗的效果较好,治疗有效率更高,肝功能指标改善程度更好,并发症发生率更低,具有较高的临床应用价值。

Objective To research the effectiveness of interventional treatment for patients with middle and advanced stage liver cancer,in order to provide reference experience for clinical practice.Methods A total of 80 patients with middle and advanced stage liver cancer who received treatment at Tengzhou Central People's Hospital from May 2019 to May 2022 were selected as the study subjects.They were randomly divided into conventional treatment group and intervention treatment group,with 40 cases in each group,using random number table method.Patients in the conventional treatment group received conventional drug treatment,while those in the intervention treatment group received intervention treatment.The clinical efficacy,liver function indicators(including ALT,TBIL,AFP and ALB)before and after treatment and the incidence of complications during treatment between two groups of patients were compared.Results The total effective rate in the intervention treatment group was 95.00%,which was higher than 75.00%in the conventional treatment group,and the difference was statistically significant(χ^(2)=6.275,P<0.05).Before treatment,there were no statistically significant differences in various indicators of liver function between the two groups(P>0.05);after treatment,the liver function indicators of the two groups were better than those before treatment,and the intervention treatment group had better liver function indicators than the conventional treatment group,and the differences were statistically significant(P<0.05).The incidence of complications in the intervention treatment group was 7.50%,which was significantly lower than 27.50%in the conventional treatment group,and the difference was statistically significant(χ^(2)=5.541,P<0.05).Conclusion Compared to conventional drug therapy,interventional therapy for patients with middle and advanced stage liver cancer had a better effect,higher treatment effectiveness,better improvement of liver function indicators,lower incidence of complications,and higher clinical application value.