基于数据挖掘曾庆琪教授辨治勃起功能障碍学术思想的研究

Research on Professor Zeng Qingqi’s academic thought on the diagnosis and treatment of erectile dysfunction based on data mining

目的探讨第七批全国老中医药专家学术经验继承工作指导老师曾庆琪教授治疗勃起功能障碍(ED)的学术经验,传承名中医学术思想。方法收集2021年10月1日至2022年7月31日南京中医药大学第一临床医学院男科门诊曾庆琪教授治疗ED的有效处方,将药物及治疗病证录入中医传承辅助平台V3.0进行数据分析。结果共收集曾庆琪教授治疗ED有效处方252首。性味分析显示,温性药物使用频次最高,寒性药物其次;甘味药物使用频次最高,辛味药物其次;归经分析显示,归肝经药物使用频次最高,归肾经药物其次;功效分析显示,补虚类药物使用频次最高,理气类药物其次;药物频次分析、用药模式分析、用药规则分析、网络拓扑分析结果显示,曾庆琪教授治疗ED常用药物是柴胡、白芍、甘草、枳壳、生地黄、山茱萸、山药、泽泻、丹皮、茯苓、附子、桂枝。聚类分析得到新方三首。结论曾庆琪教授创新男性奇恒之腑理论,提出“早泄阳痿躁郁论”学术理论,认为ED的基本病机是肝郁肾虚,以通补并用为治疗大法,以疏肝补肾为治疗原则,临证擅长以四逆散合金匮肾气丸为基础方灵活化裁治疗各型ED。

Objective To explore the academic experience and thought of Professor Zeng Qingqi,a guidance teacher for inheriting the academic experience of seventh batches of national veteran traditional Chinese medicine experts,on the treatment of erectile dysfunction(ED),and inherit the academic ideas of famous traditional Chinese medicine.Method The effective prescriptions of Professor Zeng Qingqi on ED treatment were collected from Andrology Department of the First Clinical School of Nanjing University of Traditional Chinese Medicine from October 1,2021 to July 31,2022,and the used drugs and treatment symptoms were input into the Chinese Medicine Inheritance Assistance Platform V3.0 for data analysis.Result A total of 252 effective prescriptions on ED treatment were collected.Nature and taste analysis showed that warm drugs were used the most frequently,followed by cold drugs;Sweet drugs had the highest frequency of use,followed by spicy drugs;The analysis of meridian tropism showed that the frequency of drugs targeting the liver meridian was the highest,followed by drugs targeting the kidney meridian;The efficacy analysis showed that the use frequency of tonifying deficiency drugs was the highest,followed by regulating qi drugs;The results of drug frequency analysis,drug use pattern analysis,drug use rule analysis and network topology analysis showed that the commonly used drugs for ED treatment included Bupleuri radix,Paeoniae radix alba,Glycyrrhizae radix et rhizoma,Aurantii fructus,Rehmanniae radix,Corni fructus,Dioscoreae rhizoma,Alismatis rhizoma,Moutan cortex,Poria,Aconiti lateralis radix praeparata,and Cinnamomi ramulus.Cluster analysis obtained three new prescriptions.Conclusion Professor Zeng Qingqi has updated the theory of male Qi Heng Fu and proposed the academic theory of“premature ejaculation,impotence,and irritability depression”.He believes that the basic pathogenesis of ED is liver depression and kidney deficiency,and the treatment method is to use both tonifying and tonifying,and the treatment principle is to soothe the liver and tonify the kidney.He is skilled in using the combination of Sini San and Jin Kui Shen Qi pill as the basis for treatment of various types of ED through flexible modification.