放射性粒子植入治疗前列腺癌的研究进展

Research progress of radioactive particle implantation in treatment of prostate cancer

前列腺癌(prostatecancer,PCa)是发生在前列腺的上皮性恶性肿瘤,是男性泌尿生殖系统常见的恶性肿瘤。粒子植入全称为“放射性粒子植入治疗技术”,是一种将^(125)I或^(103)Pd等含放射性的粒子按计划植入肿瘤内部以摧毁肿瘤的治疗手段。现代前列腺粒子植入治疗是一种经会阴、经直肠超声引导的技术,具有微创、损伤小、术后恢复快、最大程度地保留前列腺功能及尿道功能等优势。本文将从粒子植入的定位手段、单一治疗和联合治疗的疗效、并发症及其他相关研究等方面探讨粒子植入治疗的潜力、患者选择及未来的发展方向。

Prostate cancer(PCa)is an epithelial malignant tumor that occurs in the prostate,and is a common malignant tumor of the male genitourinary system.Particle implantation,which stands for"radioactive particle implantation therapy technology"is a treatment that implants radioactive particles such as^(125)I or^(103)Pd into the tumor as planned to destroy the tumor.Modern prostate particle implantation is a technique under the guidance of transperineal and transrectal ultrasound,which has the advantages of minimal invasion,small injury,quick postoperative recovery,and maximum preservation of the functions of prostate and urethral.This article will discuss the potential of particle implantation,patient selection and future development direction from the aspects of positioning means of particle implantation,efficacy of single therapy and combination therapy,complications and other related studies.