摘要
脂滴是一种动态的多功能细胞器,由中性脂质核心和由一组特定蛋白质修饰的磷脂单层膜构成,PAT家族蛋白是最具特征的脂滴相关蛋白,在调节脂滴结构、功能和代谢中具有重要作用。脂滴的生物发生包括中性脂的合成、脂滴的成核、出芽和生长。脂滴不仅是细胞的能量代谢库,还参与细胞内信号传导、炎症及肿瘤的发生发展,脂滴还与多种细胞器紧密连接,相互作用,并调节细胞器的分裂、运输和遗传。脂滴生物发生的复杂性及其功能的多样性可能为脂滴在疾病的发生发展中提供了一定的生理学基础,其相关的机制仍需要进一步研究。目前的研究阐述了脂滴与某些疾病的联系,比如肥胖、非酒精性脂肪肝、神经退行性变性疾病、癌症、心血管病等,但脂滴和口腔疾病的联系还未得到充分的研究。探究脂滴在口腔疾病发生发展中的作用以及相关机制,进一步了解口腔疾病与全身系统性疾病的关系,以及如何将脂滴对口腔疾病的影响转化为具有实际应用价值的临床诊疗手段,值得进一步研究。本文就脂滴的生物发生、脂滴的功能以及脂滴在口腔疾病如口腔肿瘤、牙周炎和龋病中的研究进展做一综述。
Lipid droplets are dynamic multifunctional organelles composed of a neutral lipid core and a phospholipid monolayer membrane modified by a specific set of proteins.PAT family proteins are the most characteristic lipid droplet proteins,playing an important role in regulating lipid droplet structure,function,and metabolism.The biogenesis of lipid droplets involves neutral lipid synthesis and the nucleation,budding,and growth of the lipid droplets.Lipid droplets not only serve as the energy metabolism reserve of cells but also participate in intracellular signal transduction and the development of inflammation and tumor.Lipid droplets are closely connected to and interact with various organelles,regulating the division,the transportation,and the genetics of organelles.The complexity of lipid droplets biogenesis and the diversity of their functions may have provided a physiological basis for the pathogenesis and development of diseases,but further research is needed in order to better understand the relevant processes.Published findings have helped elucidate the association between lipid droplets and diseases,such as obesity,non-alcoholic fatty liver disease,neurodegenerative disease,cancer,and cardiovascular disease,but the relationship between lipid droplets and oral diseases has not been fully studied.Topics that warrant further research include the role and mechanisms of lipid droplets in the pathogenesis and development of oral diseases,the relationship between oral diseases and systemic diseases,and translation of the effect of lipid droplets on oral diseases into valuable clinical diagnostic and treatment methods.Herein,we reviewed the biogenesis and functions of lipid droplets and the progress in research concerning lipid droplets in oral diseases,including mouth neoplasms,periodontitis,and dental caries.
作者
徐思群
魏洁雅
谢静
XU Siqun;WEI Jieya;XIE Jing(State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases and West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China)
出处
《四川大学学报(医学版)》
CAS
CSCD
北大核心
2024年第2期475-481,共7页
Journal of Sichuan University(Medical Sciences)
基金
国家自然科学基金(No.81771047)
四川省科技创新人才项目(No.2022JDRC0044)资助。
关键词
脂滴
口腔肿瘤
牙周炎
龋病
综述
Lipid droplets
Mouth neoplasms
Periodontitis
Dental caries
Review