疏肝滋肾方联合穴位针刺治疗对DOR患者IVF-ET妊娠结局的影响

Effect of Shugan Zishen Prescription combined with acupoint acupuncture treatment on pregnancy outcomes of diminished ovarian reserve patients with in vitro fertilization-embryo transfer

目的探讨疏肝滋肾方联合穴位针刺治疗方案对卵巢储备功能下降(DOR)患者体外受精-胚胎移植(IVF-ET)妊娠结局的影响。方法选取2020年1月至2021年12月河北省沧州中西医结合医院收治的90例DOR患者作为研究对象,随机分为对照组和观察组,各45例。对照组采用拮抗剂固定治疗方案,观察组在对照组的基础上采用疏肝滋肾方联合穴位针刺治疗。观察两组患者的生殖激素水平及人绒毛膜促性腺激素(hCG)阳性率、临床妊娠率、胚胎种植率和活产率。结果两组治疗后雌二醇(E_(2))、睾酮(T)、催乳素(PRL)水平均比治疗前升高,卵泡刺激素(FSH)、黄体生成素(LH)水平比治疗前降低,观察组生殖激素指标水平改善程度均显著高于对照组,差异均具有统计学意义(P<0.05)。观察组hCG阳性率、临床妊娠率、胚胎种植率、活产率均高于对照组,差异均具有统计学意义(P<0.05)。结论疏肝滋肾方联合穴位针刺治疗能改善DOR患者的卵巢储备功能,提高DOR患者IVF-ET的妊娠率。

Objective To explore the effect of the combination of Shugan Zishen Prescription combined with acupoint acupuncture treatment on pregnancy outcomes of diminished ovarian reserve(DOR)patients with in vitro fertilization-embryo transfer(IVF-ET).Methods A total of 90 DOR patients admitted to Hebei Cangzhou Integrated Traditional and Western Medicine Hospital from January 2020 to December 2021 were selected as the study subjects.They were randomly divided into a control group and an observation group,with 45 cases in each group.The control group received fixed treatment with antagonists,while the observation group received treatment with Shugan Zishen Prescription combined with acupoint acupuncture on the basis of the control group.The reproductive hormones levels,positive rate of human chorionic gonadotropin(hCG),clinical pregnancy rate,embryo implantation rate,and live birth rate of the patients in two groups were observed.Results After treatment,the levels of estradiol(E_(2)),testosterone(T),and prolactin(PRL)increased in both groups compared to those before treatment,while the levels of follicle stimulating hormone(FSH)and luteinizing hormone(LH)decreased compared to those before treatment.The improvement of reproductive hormone indicators levels in the observation group was significantly higher than that in the control group,and the differences were all statistically significant(P<0.05).The positive rate of hCG,clinical pregnancy rate,embryo implantation rate,and live birth rate in the observation group were all higher than those in the control group,and the differences were all statistically significant(P<0.05).Conclusions Shugan Zishen Prescription combined with acupoint acupuncture treatment can improve ovarian reserve function in DOR patients and increase the pregnancy rate of DOR patients with IVF-ET.