接受不同抗逆转录病毒治疗方案的HIV感染者血浆中可溶性炎症标志物水平差异研究

Study on differences in levels of plasma soluble inflammatory markers between human immunodeficiency virus-infected patients receiving different anti-retroviral therapy regimen

目的探究接受不同抗逆转录病毒治疗(ART)方案的人类免疫缺陷病毒(HIV)感染者血浆中可溶性炎症标志物表达水平的差异。方法选取2019年6月至2021年6月于海南省中医院就诊的初诊HIV感染者100例,随机将患者分为非核苷类逆转录酶抑制剂(NNRTI)组和整合酶链转移抑制剂(INSTI)组,各50例。所有患者基础用药为恩曲他滨替诺福韦片,NNRTI组患者联用依非韦伦片,INSTI组患者联用拉替拉韦钾片。分别于治疗前及治疗6个月后随访,比较两组患者血生化指标、T细胞计数、病毒学指标、炎性细胞因子表达。结果治疗6个月后两组患者血生化指标、T细胞计数、病毒学指标及血浆炎性细胞因子表达水平较治疗前均有显著差异(P<0.05),且INSTI组患者各项指标改变更显著(P<0.05)。结论相比NNRTI,应用INSTI更有助于降低HIV感染者全身炎症水平,且药物抑制病毒效果显著。

Objective To investigate differences in the expression levels of soluble inflammatory markers in the plasma of human immunodeficiency virus(HIV)-infected patients receiving different anti-retroviral therapy(ART)regimen.Methods A total of 100 newly diagnosed HIV-infected patients in Hainan Provincial Hospital of Traditional Chinese Medicine from June 2019 to June 2021 were selected and randomly divided into non-nucleoside reverse transcriptase inhibitors(NNRTI)group and integrase strand transfer inhibitors(INSTI)groups,with 50 patients in each group.All patients were given emtricitabine tenofovir as the base drug,NNRTI patients were combined with efavirenz tablets,and INSTI patients were combined with raltegravir tablets.Patients were followed up before and 6 months after treatment,respectively.Blood biochemical indexes,T-cell count,virological indexes and inflammatory cytokines expression were compared between the two groups.Results After 6 months of treatment,there were significant differences in blood biochemical indexes,T-cell count,virological indexes and plasma inflammatory cytokine expression levels compared with those before treatment in the two groups(P<0.05),and INSTI group patients had more significant changes in various indexes(P<0.05).Conclusions Compared with NNRTI,the usage of INSTI is more helpful to reduce the inflammation levels in HIV-infected patients,and the drug has significant viral suppression effect.