摘要
本文报道1对父子克罗恩病(CD)患者伴有NOD样受体家族含pyrin结构域12(NLRP12)基因c.1382移码变异病例,结合文献复习对国内外其他CD合并NLRP12基因突变的病例及NLRP12在炎症性肠病中的作用机制研究进行归纳,为后续个体化治疗的探索提供参考。
A pair of father-son Crohn′s disease(CD)patients with NOD-like receptors family pyrin domain containing 12(NLRP12)gene c.1382 mutation was reported.Through the relevant literature review,we summarize the other CD patients complicated with NLRP12 genetic variation at home and abroad and the mechanism of NLRP12 in inflammatory bowel disease.This study aims to provide reference for the subsequent exploration of individulized treatment.
作者
刘若冰
李祥苏
黄杨
李爱兰
温芬
赵雪
王超楠
肖雪怡
杨青青
吴旭东
Liu Ruobing;Li Xiangsu;Huang Yang;Li Ailan;Wen Fen;Zhao Xue;Wang Chaonan;Xiao Xueyi;Yang Qingqing;Wu Xudong(Department of General Practice,the Yancheng Clinical College of Xuzhou Medical University,the First People′s Hospital of Yancheng,Yancheng 224006,China;Department of Gastroenterology,the Yancheng Clinical College of Xuzhou Medical University,the First People′s Hospital of Yancheng,Yancheng 224006,China)
出处
《中华炎性肠病杂志（中英文）》
2024年第1期101-104,共4页
Chinese Journal of Inflammatory Bowel Diseases
