肝酶对钢铁工人代谢健康型肥胖与高尿酸血症关联影响

Effect of liver enzymes on association between metabolically healthy obesity and hyperuricemia in steelworkers

为探讨代谢健康型肥胖(MHO)和高尿酸血症(HUA)之间的关系,以及肝酶相关异常对此关系的影响,采用横断面研究,以参加河北钢铁公司职业体检的6868名钢铁工人为研究对象,采用logistic回归模型和交互效应模型进行数据分析。结果表明:在校正混杂因素后,代谢健康全身肥胖的钢铁工人患HUA的风险增加2.13倍(比值比OR=2.13,95%置信区间CI:1.08~4.21);代谢健康腹型肥胖的钢铁工人患HUA的风险增加2.25倍(OR=2.25,95%CI:1.14~4.45)。在分层分析中,肝酶升高组MHO的钢铁工人HUA患病率显著高于肝酶正常组,不同肥胖表型和肝酶水平之间存在交互作用(P<0.05)。MHO与HUA的高患病率相关。肝酶升高可能改变MHO和HUA之间的关系。

The association between MHO and HUA and whether liver enzyme abnormalities could modify this association were studied.The cross-sectional study was conducted using 6,868 steelworkers in Hebei Iron and Steel Company who participated in occupational medical examinations as the study population.The data were analyzed using logistic regression models and interaction effect model.The results show that,in a multiple adjusted logistic model,the risk of HUA is increased 2.13-fold(odds ratio(OR)=2.13,95%confidence interval(CI):1.08-4.21)for metabolically healthy generalized obesity(MHGO).The risk of HUA is increased 2.25-fold(OR=2.25,95%CI:1.14-4.45)for metabolically healthy abdominal obesity(MHAO).In stratified analysis,in the group with elevated liver enzymes,the prevalence of HUA in steelworkers with MHO(MHGO and MHAO)is significantly higher than that in the group with normal liver enzymes,and the interaction between obesity phenotypes and liver enzyme levels has a statistically significant effect on HUA(P<0.05).MHO is associated with a high prevalence of HUA.Liver enzyme levels may alter the relationship between MHO and HUA.