SET-CAN/WT1融合基因阳性的T细胞急性淋巴细胞白血病1例伴文献复习

A case of SET-CAN/WT1 fusion gene positive T-cell acute lymphoblastic leukemia with literature review

T细胞急性淋巴细胞白血病(T-cell acute lymphoblastic leukemia,T-ALL)是具有高度侵袭性的恶性肿瘤之一。NOTCH1/FBXW7突变是其最常见的一种基因突变,而SET-CAN/WT1融合基因阳性的T-ALL较少见。本文报道1例SET-CAN/WT1融合基因阳性的难治性T-ALL患者,在给予多个疗程联合化疗治疗后均无明显疗效,结合相关文献复习发现,SET-CAN/WT1融合基因阳性的T-ALL患者较为罕见,具有难治性、起病急、进展快、预后差、生存期短等特点。

T-cell acute lymphoblastic leukemia(T-ALL)is one of the highly invasive malignant tumors.NOTCH1/FBXW7 mutation is the most common gene mutation,while T-ALL with positive SET-CAN/WT1 fusion gene is rare.This paper reports a case of refractory T-ALL with positive SET-CAN/WT1 fusion gene.After several courses of combined chemotherapy,there is no obvious curative effect and related literature review.It is concluded that T-ALL patients with positive SET-CAN/WT1 fusion gene are rare,with the characteristics of refractory,acute onset,rapid progress,poor prognosis and short survival time.