摘要
发展了一种无需任何添加剂,在水相中合成烷基硫代酯的绿色方法.以卤代烃与硫代酰胺为原料,在水相中反应4 h,即可以较高收率得到预期产物,并可兼容多种官能团.与传统方法相比,该方法具有实验操作简单、反应绿色高效及原子经济等优点,并且可以实现克级制备,具有较高的应用价值.
A new,green and extra additive-free synthesis method of alkyl thioesters in water media was developed in this paper.By using alkyl halides and thioamide as the raw materials,the reaction can proceed smoothly in aqueous phase for 4 h,to afford the target thioester products with high yields,and the method can be compatible with various functional groups.Compared with the available methods,this method has the advantages of simple experimental operation,green and high efficiency,good atomic economy,and can easily be scaled up in gram scale,and has high practical application value.
作者
闫晓雨
陈钰莹
赵媚
袁贻云
卞佳坤
马献涛
YAN Xiaoyu;CHEN Yuying;ZHAO Mei;YUAN Yiyun;BIAN Jiakun;MA Xiantao(College of Chemistry and Chemical Engineering,Green Catalysis&Synthesis Key Laboratory of Xinyang City,Xinyang Normal University,Xinyang 464000,China)
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2024年第4期29-34,共6页
Chemical Journal of Chinese Universities
基金
国家自然科学基金(批准号:22101243)
河南省本科高校青年骨干教师培养计划(批准号:2023GGJS097)
信阳师范大学南湖学者青年项目和信阳师范大学研究生科研创新基金(批准号:2022KYJJ013)资助。
关键词
硫酯
卤代烃
硫代酰胺
水相
Thioester
Alkyl halide
Thioamide
Water media