高压氧同步脑仿生电刺激治疗突发性耳聋患者听力与血液高凝状态的临床研究

Application of hyperbaric oxygen combined with biomimetic electrical stimulation of brain in improving hearing and hypercoagulable state in patients with sudden deafness

目的研究突发性耳聋患者应用高压氧同步脑仿生电刺激治疗对听力与血液高凝状态的疗效。方法选取突发性耳聋患者80例,随机数字表法分为对照组和试验组,每组40例。对照组采用高压氧治疗,试验组在对照组基础上同步采用脑仿生电刺激治疗。比较两组临床疗效、听阈值、耳聋评分、纤维蛋白原(FIB)、凝血酶原时间(PT)、血浆D-二聚体(D-D)、活化部分凝血活酶时间(APTT)、焦虑自评量表(SAS)评分及抑郁自评量表(SDS)评分。结果治疗后,试验组总有效率高于对照组(χ^(2)=7.31,P<0.05),听阈值、耳聋评分、FIB、D-D、SAS及SDS低于对照组(t分别=14.13、16.45,6.54、3.68、15.82、17.83,P均<0.05),PT、APTT高于对照组,差异均有统计学意义(t分别=-3.77、-4.37,P均<0.05)。结论较单一应用高压氧治疗,高压氧同步脑仿生电刺激治疗的疗效更为显著,在改善突发性耳聋患者的听力优势更为显著。

Objective To study the effect of hyperbaric oxygen with biomimetic electrical stimulation of brain on hear⁃ing and hypercoagulable state in patients with sudden deafness.Methods A total of 80 patients with sudden deafness were selected and randomly divided into control group and experimental group,with 40 cases in each group.The control group was given hyperbaric oxygen therapy,while the experimental group was given biomimetic electrical stimulation of brain on the basis of the treatment of control group.Comparison between two groups was made on clinical efficacy,audito⁃ry threshold,deafness score,fibrinogen(FIB),prothrombin time(PT),plasma D-dimer(D-D),activated partial throm⁃boplastin time(APTT),self-rating anxiety scale(SAS),and self-rating depression scale(SDS)scores.Results After treatment,the total effective rate in the experimental group was higher than that in the control group(χ^(2)=7.31,P<0.05).The auditory threshold,deafness score,FIB,D-D,SAS and SDS scores were lower than those of the control group(t=14.13,16.45,6.54,3.68,15.82,17.83,P<0.05).While the PT and APTT were longer than those in the control group(t=-3.77,-4.37,P<0.05).Conclusion Compared with simple hyperbaric oxygen therapy,hyperbaric oxygen combined with biomimetic electrical stimulation of brain is more effective in the treatment of patients with sudden deafness,espe⁃cially in improving the patients’hearing.